| February 2022 |
| Date | Time | Opponent | Venue | Result |
| Sat. 12 | 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET20:00 GMT21:00 20:00 8:00 PM 22:00 KSA7:00 AM AET1:30 (+1) IST3:30 PM VEN0:00 (+1) UAE4:00 AM SST4:00 3:00 1:00 PM MST2:00 PM CST3:00 PM EST15:00 ET15:00 16:00 BRT16:00 1:00 PM CT | Lanús | Estadio Tomas Adolfo Duco | W 1-0 |
| Tue. 15 | 4:30 PM PT5:30 PM MT6:30 PM CT7:30 PM ET0:30 (+1) GMT1:30 0:30 12:30 AM 2:30 KSA11:30 AM AET6:00 (+1) IST8:00 PM VEN4:30 (+1) UAE8:30 AM SST8:30 7:30 5:30 PM MST6:30 PM CST7:30 PM EST19:30 ET19:30 20:30 BRT20:30 5:30 PM CT | Estudiantes | Estadio Tomas Adolfo Duco | L 2-3 |
| Sat. 19 | 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET20:00 GMT21:00 20:00 8:00 PM 22:00 KSA7:00 AM AET1:30 (+1) IST3:30 PM VEN0:00 (+1) UAE4:00 AM SST4:00 3:00 1:00 PM MST2:00 PM CST3:00 PM EST15:00 ET15:00 16:00 BRT16:00 1:00 PM CT | Arsenal | Estadio Julio Humberto Grondona | L 1-2 |
| Thu. 24 | 4:30 PM PT5:30 PM MT6:30 PM CT7:30 PM ET0:30 (+1) GMT1:30 0:30 12:30 AM 2:30 KSA11:30 AM AET6:00 (+1) IST8:00 PM VEN4:30 (+1) UAE8:30 AM SST8:30 7:30 5:30 PM MST6:30 PM CST7:30 PM EST19:30 ET19:30 21:30 BRT20:30 5:30 PM CT | Vélez Sarsfield | Estadio Tomas Adolfo Duco | W 2-0 |
| March 2022 |
| Date | Time | Opponent | Venue | Result |
| Sun. 6 | 2:15 PM PT3:15 PM MT4:15 PM CT5:15 PM ET22:15 GMT23:15 22:15 10:15 PM 0:15 KSA9:15 AM AET3:45 (+1) IST5:45 PM VEN2:15 (+1) UAE6:15 AM SST6:15 5:15 3:15 PM MST4:15 PM CST5:15 PM EST17:15 ET17:15 19:15 BRT18:15 3:15 PM CT | Boca Juniors | Estadio Alberto Jose Armando | W 1-0 |
| Sat. 12 | 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET20:00 GMT21:00 20:00 8:00 PM 22:00 KSA7:00 AM AET1:30 (+1) IST3:30 PM VEN0:00 (+1) UAE4:00 AM SST4:00 3:00 1:00 PM MST2:00 PM CST3:00 PM EST15:00 ET15:00 17:00 BRT16:00 1:00 PM CT | Godoy Cruz | Estadio Tomas Adolfo Duco | L 1-3 |
| Sat. 19 | 12:15 PM PT1:15 PM MT2:15 PM CT3:15 PM ET19:15 GMT20:15 19:15 7:15 PM 21:15 KSA6:15 AM AET0:45 (+1) IST2:45 PM VEN23:15 UAE3:15 AM SST3:15 2:15 12:15 PM MST1:15 PM CST2:15 PM EST15:15 ET14:15 16:15 BRT15:15 1:15 PM CT | San Lorenzo | Estadio Pedro Bidegain | D 0-0 |
| April 2022 |
| Date | Time | Opponent | Venue | Result |
| Fri. 1 | 3:00 PM PT4:00 PM MT5:00 PM CT6:00 PM ET22:00 GMT23:00 22:00 10:00 PM 0:00 KSA9:00 AM AET3:30 (+1) IST5:30 PM VEN2:00 (+1) UAE6:00 AM SST6:00 5:00 3:00 PM MST4:00 PM CST5:00 PM EST18:00 ET17:00 19:00 BRT18:00 4:00 PM CT | Central Cordoba SdE | Estadio Unico Madre de Ciudades | D 2-2 |
| Mon. 11 | 3:00 PM PT4:00 PM MT5:00 PM CT6:00 PM ET22:00 GMT23:00 22:00 10:00 PM 0:00 KSA9:00 AM AET3:30 (+1) IST5:30 PM VEN2:00 (+1) UAE6:00 AM SST6:00 5:00 3:00 PM MST4:00 PM CST5:00 PM EST18:00 ET17:00 19:00 BRT18:00 5:00 PM CT | Barracas Central | Estadio Tomas Adolfo Duco | L 1-2 |
| Fri. 15 | 12:30 PM PT1:30 PM MT2:30 PM CT3:30 PM ET19:30 GMT20:30 19:30 7:30 PM 21:30 KSA6:30 AM AET1:00 (+1) IST3:00 PM VEN23:30 UAE3:30 AM SST3:30 2:30 12:30 PM MST1:30 PM CST2:30 PM EST15:30 ET14:30 16:30 BRT15:30 2:30 PM CT | Tigre | Estadio Jose Dellagiovanna | L 1-2 |
| Tue. 19 | 3:00 PM PT4:00 PM MT5:00 PM CT6:00 PM ET22:00 GMT23:00 22:00 10:00 PM 0:00 KSA9:00 AM AET3:30 (+1) IST5:30 PM VEN2:00 (+1) UAE6:00 AM SST6:00 5:00 3:00 PM MST4:00 PM CST5:00 PM EST18:00 ET17:00 19:00 BRT18:00 5:00 PM CT | Colón | Estadio Tomas Adolfo Duco | |
| Mon. 25 | 5:30 PM PT6:30 PM MT7:30 PM CT8:30 PM ET0:30 (+1) GMT1:30 0:30 12:30 AM 2:30 KSA11:30 AM AET6:00 (+1) IST8:00 PM VEN4:30 (+1) UAE8:30 AM SST8:30 7:30 5:30 PM MST6:30 PM CST7:30 PM EST20:30 ET19:30 21:30 BRT20:30 7:30 PM CT | Aldosivi | Estadio Jose Maria Minella | |
| Sat. 30 | TBA | Rosario Central | Estadio Tomas Adolfo Duco | |
| May 2022 |
| Date | Time | Opponent | Venue | Result |
| Sun. 8 | TBA | Independiente | Estadio Libertadores de America | |
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