| Scoring Summary |
| First Quarter |
Lou | Duke |
| Lou |
TD |
10:10 |
Trevion Cooley 48 yd pass from Malik Cunningham (James Turner kick) |
7 |
0 |
| Duke |
FG |
5:33 |
Charlie Ham 22 yd FG |
7 |
3 |
| Lou |
TD |
0:58 |
Marshon Ford 20 yd pass from Malik Cunningham (James Turner kick) |
14 |
3 |
| Second Quarter |
Lou | Duke |
| Lou |
TD |
11:26 |
Malik Cunningham 44 yd run (James Turner kick) |
21 |
3 |
| Duke |
FG |
8:34 |
Charlie Ham 28 yd FG |
21 |
6 |
| Lou |
TD |
7:29 |
Malik Cunningham 72 yd run (James Turner kick) |
28 |
6 |
| Lou |
TD |
1:36 |
Jalen Mitchell 11 yd run (James Turner kick) |
35 |
6 |
| Duke |
FG |
0:00 |
Charlie Ham 26 yd FG |
35 |
9 |
| Third Quarter |
Lou | Duke |
| Lou |
TD |
7:46 |
Jordan Watkins 19 yd pass from Malik Cunningham (James Turner kick) |
42 |
9 |
| Duke |
TD |
5:06 |
Jalon Calhoun 6 yd run (Charlie Ham kick) |
42 |
16 |
| Lou |
TD |
3:15 |
Ahmari Huggins-Bruce 12 yd pass from Malik Cunningham (missed kick) |
48 |
16 |
| Fourth Quarter |
Lou | Duke |
| Duke |
TD |
14:54 |
Riley Leonard 35 yd run (failed 2pt rush) |
48 |
22 |
| Lou |
TD |
12:17 |
Tyler Harrell 36 yd pass from Malik Cunningham (James Turner kick) |
55 |
22 |
| Lou |
TD |
5:10 |
Aidan Robbins 34 yd run (Brock Travelstead kick) |
62 |
22 |
