KANSAS CITY, Mo. (AP) Kyle Shanahan was watching as Jimmy Garoppolo scrambled toward the 49ers sideline and, rather than safely duck out of bounds, stepped back to his right and took a wicked shot from Steven Nelson.

At first, the San Francisco coach thought his quarterback had sustained a concussion.

Turns out it may have been a season-ending knee injury.

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DETROIT (AP) Matt Patricia weaved his way through a crowd to hug the man who helped him live a dream.

Patricia beat mentor Bill Belichick, seemingly making all the right moves to help the Detroit Lions defeat the New England Patriots 26-10 Sunday night.

KANSAS CITY, Mo. (AP) Patrick Mahomes was flushed from the pocket and scrambled all the way to his left, only to realize that just about everybody wearing a Chiefs helmet was on the opposite side of the field.

It was a rookie mistake by the second-year pro, one he turned into more early season magic.

PHILADELPHIA (AP) Carson Wentz shook off rust and defenders.

Wentz threw a touchdown pass on his first drive in nine months, Wendell Smallwood ran in from the 4 for the go-ahead score and the Philadelphia Eagles held on for a 20-16 victory over the Indianapolis Colts on Sunday.

MINNEAPOLIS (AP) Josh Allen played with the poise of a well-seasoned quarterback, hustling to give Buffalo an early lead in his first NFL road start.

Then, the Bills turned their defense loose on Kirk Cousins and delivered a stunningly lopsided victory over the Minnesota Vikings.

LANDOVER, Md. (AP) Green Bay Packers linebacker Clay Matthews does not understand why he was flagged - yet again - for roughing the passer, this time while sacking Washington's Alex Smith on Sunday. Matthews think it's an indication that the NFL is "getting soft."

Even Smith wasn't quite sure about the call that came late in the third quarter of Washington's 31-17 victory. Neither were other players - or the coaches - from both teams. Matthews broke free into the backfield, grabbed Smith with both arms and took down the QB in a seemingly straightforward manner.

ATLANTA (AP) On the day he became the NFL's career leader in completed passes, Drew Brees' biggest plays came as a runner.

Brees' 1-yard run capped an 80-yard touchdown drive to open overtime that lifted the New Orleans Saints to a 43-37 win over the Atlanta Falcons on Sunday.

PHILADELPHIA (AP) Tommy McDonald, the small, speedy and sure-handed receiver who teamed with quarterback Norm Van Brocklin to help the Philadelphia Eagles win the 1960 NFL championship, has died. He was 84.

His death was announced Monday by the Pro Football Hall of Fame. Details were not disclosed.

JACKSONVILLE, Fla. (AP) Marcus Mariota just has a knack for beating Jacksonville.

He's done it with his arm. He's done it with his legs. Now he's done it off the bench.

LANDOVER, Md. (AP) A week removed from what he called "an embarrassment," Adrian Peterson turned in his first 100-yard game in more than 10 months.

Peterson ran for 120 yards and a pair of 2-yard scores, Alex Smith threw two touchdown passes and the Washington Redskins held on Sunday for a 31-17 victory over a gimpy Aaron Rodgers and the Green Bay Packers, who again had complaints about a roughing-the-passer penalty on Clay Matthews.