Transactions
| Date | Player | Pos | Transactions |
| 1/28 | Marcus Kemp | WR | active/prac. squad |
| 1/28 | Ihmir Smith-Marsette | WR | active/prac. squad |
| 1/28 | La'Mical Perine | RB | pract. squad add |
| 1/28 | Jerrion Ealy | WR | pract. squad del |
| 1/23 | Marcus Kemp | WR | pract. squad add |
| 1/23 | Austin Reiter | C | pract. squad add |
| 1/23 | Chris Lammons | CB | cut |
| 1/20 | Marcus Kemp | WR | active/prac. squad |
| 1/20 | Austin Reiter | C | active/prac. squad |
| 1/17 | Jerrion Ealy | WR | pract. squad add |
| 1/17 | Daniel Wise | DT | pract. squad del |
| 1/12 | Phil Hoskins | DT | pract. squad add |
| 1/12 | Jerrion Ealy | WR | pract. squad del |
| 1/9 | Ihmir Smith-Marsette | WR | pract. squad add |
| 1/9 | Matthew Wright | K | pract. squad add |
| 1/6 | Ihmir Smith-Marsette | WR | active/prac. squad |
| 1/6 | Matthew Wright | K | pract. squad add |
| 1/6 | Matthew Wright | K | active/prac. squad |
| 1/6 | Justin Hilliard | LB | pract. squad del |
| 1/4 | Geron Christian Sr. | T | cut |
| 1/4 | Daniel Wise | DT | pract. squad add |
| 1/4 | Bryan Edwards | WR | pract. squad del |
| 1/3 | Cornell Powell | WR | pract. squad del |
| 1/3 | Jerrion Ealy | WR | pract. squad add |
| 12/28 | Justin Hilliard | LB | pract. squad add |
| 12/27 | Jerrion Ealy | WR | pract. squad del |
| 12/25 | Danny Shelton | DT | pract. squad add |
| 12/23 | Danny Shelton | DT | active/prac. squad |
| 12/20 | Matt Bushman | TE | pract. squad add |
| 12/12 | Ihmir Smith-Marsette | WR | pract. squad add |
| 12/10 | Ihmir Smith-Marsette | WR | active/prac. squad |
| 12/8 | Brandon Williams | DT | active/prac. squad |
| 12/8 | Austin Reiter | C | pract. squad add |
| 12/6 | Taylor Stallworth | DT | cut |
| 12/5 | Zayne Anderson | CB | pract. squad add |
| 12/5 | Cornell Powell | WR | pract. squad add |
| 12/3 | Zayne Anderson | CB | active/prac. squad |
| 12/3 | Cornell Powell | WR | active/prac. squad |
| 11/30 | Brandon Williams | DT | pract. squad add |
| 11/29 | Melvin Gordon III | RB | pract. squad add |
| 11/29 | Wayne Gallman Jr. | RB | pract. squad del |
| 11/29 | Austin Reiter | C | pract. squad del |
| 11/28 | Zayne Anderson | CB | pract. squad add |
| 11/28 | Cornell Powell | WR | pract. squad add |
| 11/28 | Bryan Edwards | WR | pract. squad add |
| 11/28 | Azur Kamara | DE | pract. squad del |
| 11/26 | Zayne Anderson | CB | active/prac. squad |
| 11/26 | Cornell Powell | WR | active/prac. squad |
| 11/23 | Lucas Niang | T | Activated from PUPL |
| 11/23 | Kendall Blanton | TE | pract. squad add |
| 11/23 | Jordan Franks | TE | pract. squad del |
| 11/21 | Marcus Kemp | WR | pract. squad add |
| 11/21 | Cornell Powell | WR | pract. squad add |
| 11/19 | Marcus Kemp | WR | active/prac. squad |
| 11/19 | Cornell Powell | WR | active/prac. squad |
| 11/17 | Frank Clark | DE | reinstated |
| 11/14 | Ugo Amadi | S | pract. squad add |
| 11/14 | Frank Clark | DE | suspension lifted |
| 11/14 | Frank Clark | DE | Exempt/Commissioner's Permission List |
| 11/14 | Jerrion Ealy | WR | pract. squad add |
| 11/12 | Ugo Amadi | S | active/prac. squad |
| 11/7 | Marcus Kemp | WR | pract. squad add |
| 11/5 | Marcus Kemp | WR | active/prac. squad |
| 11/3 | Ugo Amadi | S | pract. squad add |
| 11/3 | Dazz Newsome | WR | pract. squad del |
| 11/1 | Azur Kamara | DE | pract. squad add |
| 11/1 | Dazz Newsome | WR | pract. squad add |
| 10/27 | Kadarius Toney | WR | traded for 2023 3rd- and 6th-round draft picks |
| 10/25 | Frank Clark | DE | suspended 2 games (NFL Personal Conduct Policy) |
| 10/25 | Daurice Fountain | WR | pract. squad del |
| 10/24 | Dicaprio Bootle | CB | pract. squad add |
| 10/24 | Marcus Kemp | WR | pract. squad add |
| 10/22 | Dicaprio Bootle | CB | active/prac. squad |
| 10/22 | Marcus Kemp | WR | active/prac. squad |
| 10/21 | Ihmir Smith-Marsette | WR | pract. squad add |
| 10/20 | Dicaprio Bootle | CB | pract. squad add |
| 10/17 | Zayne Anderson | CB | pract. squad add |
| 10/17 | Cole Christiansen | LB | pract. squad add |
| 10/17 | Dicaprio Bootle | CB | cut |
| 10/17 | Willie Gay Jr. | LB | suspension lifted |
| 10/15 | Dicaprio Bootle | CB | active/prac. squad |
| 10/15 | Zayne Anderson | CB | active/prac. squad |
| 10/15 | Cole Christiansen | LB | active/prac. squad |
| 10/15 | Tershawn Wharton | DT | on IR knee |
| 10/14 | Benton Whitley | LB | pract. squad add |
| 10/12 | Taylor Stallworth | DT | active/prac. squad |
| 10/12 | Wayne Gallman Jr. | RB | pract. squad add |
| 10/12 | Benton Whitley | LB | cut |
| 10/11 | Elijah Lee | LB | pract. squad add |
| 10/11 | Matthew Wright | K | pract. squad add |
| 10/11 | Cortez Broughton | DT | pract. squad del |
| 10/10 | Elijah Lee | LB | active/prac. squad |
| 10/10 | Matthew Wright | K | active/prac. squad |
| 10/6 | Chris Conley | WR | pract. squad add |
| 10/4 | Corey Coleman | WR | pract. squad del |
| 10/3 | Elijah Lee | LB | pract. squad add |
| 10/3 | Matthew Wright | K | pract. squad add |
| 10/3 | Marcus Kemp | WR | pract. squad add |
| 10/3 | Jerrion Ealy | WR | pract. squad del |
| 10/1 | Elijah Lee | LB | active/prac. squad |
| 10/1 | Matthew Wright | K | active/prac. squad |
| 9/28 | Nazeeh Johnson | S | active/prac. squad |
| 9/28 | Elijah Lee | LB | pract. squad add |
| 9/28 | Matthew Wright | K | pract. squad add |
| 9/27 | Elijah Lee | LB | cut |
| 9/27 | Cortez Broughton | DT | pract. squad add |
| 9/26 | Matt Ammendola | K | pract. squad add |
| 9/26 | Dicaprio Bootle | CB | pract. squad add |
| 9/26 | Matt Ammendola | K | pract. squad del |
| 9/24 | Matt Ammendola | K | active/prac. squad |
| 9/24 | Dicaprio Bootle | CB | active/prac. squad |
| 9/21 | Benton Whitley | LB | active/prac. squad |
| 9/19 | Willie Gay Jr. | LB | suspended 4 games (NFL Personal Conduct Policy) |
| 9/16 | Matt Ammendola | K | pract. squad add |
| 9/16 | Dicaprio Bootle | CB | pract. squad add |
| 9/15 | Matt Ammendola | K | active/prac. squad |
| 9/15 | Dicaprio Bootle | CB | active/prac. squad |
| 9/13 | Jack Cochrane | LB | active/prac. squad |
| 9/13 | Elijah Lee | LB | active/prac. squad |
| 9/13 | James Wiggins | S | pract. squad del |
| 9/13 | Matt Ammendola | K | pract. squad add |
| 9/13 | Dicaprio Bootle | CB | pract. squad add |
| 9/13 | Corey Coleman | WR | pract. squad add |
| 9/12 | Daurice Fountain | WR | pract. squad add |
| 9/12 | Elijah Lee | LB | pract. squad add |
| 9/10 | Daurice Fountain | WR | active/prac. squad |
| 9/10 | Elijah Lee | LB | active/prac. squad |
| 9/7 | Matt Bushman | TE | cut |
| 9/7 | Matt Bushman | TE | off IR undisclosed |
| 9/6 | Azur Kamara | DE | pract. squad del |
| 9/6 | James Wiggins | S | pract. squad add |
| 9/2 | Kendall Blanton | TE | pract. squad add |
| 9/2 | Cole Christiansen | LB | pract. squad add |
| 8/31 | Zayne Anderson | CB | pract. squad add |
| 8/31 | Mike Caliendo | G | pract. squad add |
| 8/31 | Jack Cochrane | LB | pract. squad add |
| 8/31 | Jerrion Ealy | WR | pract. squad add |
| 8/31 | Daurice Fountain | WR | pract. squad add |
| 8/31 | Jordan Franks | TE | pract. squad add |
| 8/31 | Nazeeh Johnson | S | pract. squad add |
| 8/31 | Azur Kamara | DE | pract. squad add |
| 8/31 | Elijah Lee | LB | pract. squad add |
| 8/31 | Chris Oladokun | QB | pract. squad add |
| 8/31 | Cornell Powell | WR | pract. squad add |
| 8/31 | Austin Reiter | C | pract. squad add |
| 8/31 | Danny Shelton | DT | pract. squad add |
| 8/31 | Taylor Stallworth | DT | pract. squad add |
| 8/31 | Matt Bushman | TE | on IR undisclosed |
| 8/30 | Josh Gordon | WR | cut |
| 8/30 | Taylor Stallworth | DT | cut |
| 8/30 | Danny Shelton | DT | cut |
| 8/30 | Austin Reiter | C | cut |
| 8/30 | Zayne Anderson | CB | cut |
| 8/30 | Dicaprio Bootle | CB | cut |
| 8/30 | Mike Caliendo | G | cut |
| 8/30 | Jack Cochrane | LB | cut |
| 8/30 | Matt Dickerson | DE | cut |
| 8/30 | Jerrion Ealy | WR | cut |
| 8/30 | Jordan Franks | TE | cut |
| 8/30 | Vitaliy Gurman | G | cut |
| 8/30 | Nazeeh Johnson | S | cut |
| 8/30 | Azur Kamara | DE | cut |
| 8/30 | Devon Key | CB | cut |
| 8/30 | Kehinde Oginni Hassan | DE | cut |
| 8/30 | Cornell Powell | WR | cut |
| 8/30 | Jermaine Carter Jr. | LB | cut |
| 8/30 | Corey Coleman | WR | cut |
| 8/30 | Daurice Fountain | WR | cut |
| 8/30 | Elijah Lee | LB | cut |
| 8/27 | Dustin Crum | QB | cut |
| 8/27 | Tayon Fleet-Davis | RB | cut |
| 8/27 | Aaron Parker | WR | cut |
| 8/27 | Roderick Johnson | T | cut |
| 8/27 | Mike Rose | LB | cut |
| 8/25 | Derrick Gore | RB | cut |
| 8/25 | Derrick Gore | RB | off IR fractured thumb |
| 8/24 | Gary Jennings | WR | cut |
| 8/24 | Gary Jennings | WR | off IR undisclosed |
| 8/23 | Lucas Niang | T | Placed on PUPL knee |
| 8/23 | Derrick Gore | RB | on IR fractured thumb |
| 8/22 | Brandin Dandridge | CB | cut |
| 8/22 | Nasir Greer | CB | cut |
| 8/22 | David Steinmetz | T | cut |
| 8/16 | Austin Edwards | DE | cut |
| 8/16 | Devin Gray | WR | cut |
| 8/16 | Gary Jennings | WR | on IR undisclosed |
| 8/15 | Danny Shelton | DT | signed/unrest FA |
| 8/15 | Omar Bayless | WR | cut |
| 8/15 | Lonnie Johnson Jr. | CB | cut |
| 8/15 | Evin Ksiezarczyk | T | cut |
| 8/8 | Shilique Calhoun | LB | cut |
| 8/8 | Matt Dickerson | DE | signed |
| 8/7 | DeAndre Baker | CB | cut |
| 8/7 | Devin Gray | WR | signed |
| 8/5 | Cortez Broughton | DT | Activated from PUPL |
| 8/5 | Cortez Broughton | DT | cut |
| 8/2 | Chris Glaser | G | cut |
| 8/2 | Orlando Brown Jr. | T | re-signed/franchise One-year contract (through 2022) |
| 7/28 | Cortez Broughton | DT | Placed on PUPL |
| 7/28 | Carlos Dunlap II | DE | signed One-year contract (through 2022) |
| 7/28 | Mark Vital | TE | cut |
| 7/26 | Azur Kamara | DE | signed |
| 7/25 | Evin Ksiezarczyk | T | signed |
| 7/25 | David Steinmetz | T | signed |
| 7/25 | Justyn Ross | WR | on IR foot |
| 7/22 | Mathew Sexton | WR | cut |
| 7/22 | Mathew Sexton | WR | off IR undisclosed |
| 7/14 | Mitchell Schwartz | T | retired |
| 6/17 | Mathew Sexton | WR | on IR undisclosed |
| 6/16 | Luq Barcoo | CB | cut |
| 6/16 | Chris Lammons | CB | re-signed/unrest FA |
| 6/16 | Aaron Parker | WR | signed |
| 6/14 | Darryl Williams | C | cut |
| 6/13 | Jerick McKinnon | RB | re-signed One-year contract (through 2022) |
| 6/13 | Skyy Moore | WR | signed/draft choice Four-year contract (through 2025) |
| 6/9 | Joshua Williams | CB | signed/draft choice Four-year contract (through 2025) |
| 6/1 | Leo Chenal | LB | signed/draft choice Four-year contract (through 2025) |
| 5/31 | Jody Fortson | TE | re-signed/excl. FA One-year contract (through 2022) |
| 5/16 | Vitaliy Gurman | G | signed |
| 5/10 | Anthony Gordon | QB | cut |
| 5/10 | Brenden Knox | RB | cut |
| 5/10 | Gene Pryor | T | cut |
| 5/10 | Darius Stills | DT | cut |
| 5/10 | Chris Glaser | G | signed |
| 5/10 | Gary Jennings | WR | signed |
| 5/10 | Austin Reiter | C | signed |
| 5/9 | Mike Caliendo | G | signed |
| 5/9 | Jack Cochrane | LB | signed |
| 5/9 | Dustin Crum | QB | signed |
| 5/9 | Jerrion Ealy | WR | signed |
| 5/9 | Tayon Fleet-Davis | RB | signed |
| 5/9 | Nasir Greer | CB | signed |
| 5/9 | Kehinde Oginni Hassan | DE | signed |
| 5/9 | Gene Pryor | T | signed |
| 5/9 | Mike Rose | LB | signed |
| 5/9 | Justyn Ross | WR | signed |
| 5/9 | Bryan Cook | S | signed/draft choice Four-year contract (through 2025) |
| 5/9 | Nazeeh Johnson | S | signed/draft choice Four-year contract (through 2025) |
| 5/9 | George Karlaftis | DE | signed/draft choice Four-year contract (fifth-year option) |
| 5/9 | Trent McDuffie | CB | signed/draft choice Four-year contract (fifth-year option) |
| 5/9 | Isiah Pacheco | RB | signed/draft choice Four-year contract (through 2025) |
| 5/9 | Jaylen Watson | CB | signed/draft choice Four-year contract (through 2025) |
| 5/9 | Darian Kinnard | T | signed/draft choice Four-year contract (through 2025) |
| 5/6 | Lorenzo Neal Jr. | DT | cut |
| 5/6 | Austin Reiter | C | cut |
| 5/5 | Gehrig Dieter | WR | cut |
| 5/5 | Nakia Griffin-Stewart | TE | cut |
| 5/5 | Gary Jennings | WR | cut |
| 5/5 | Josh Pederson | TE | cut |
| 5/5 | Jonathan Woodard | DE | cut |
| 5/3 | Chris Finke | WR | cut |
| 5/2 | Lonnie Johnson Jr. | CB | traded for 2024 seventh-round draft pick |
| 4/27 | Anthony Gordon | QB | signed One-year contract (through 2022) |
| 4/7 | Derrick Gore | RB | re-signed/excl. FA One-year contract (through 2022) |
| 4/5 | Taylor Stallworth | DT | signed/unrest FA One-year contract (through 2022) |
| 3/28 | Deon Bush | S | signed/unrest FA One-year contract (through 2022) |
| 3/27 | Ronald Jones II | RB | signed/unrest FA One-year contract (through 2022) |
| 3/25 | Jermaine Carter Jr. | LB | signed/unrest FA One-year contract (through 2022) |
| 3/24 | Corey Coleman | WR | signed One-year contract (through 2022) |
| 3/24 | Luq Barcoo | CB | signed One-year contract (through 2022) |
| 3/24 | Geron Christian Sr. | T | signed/unrest FA One-year contract (through 2022) |
| 3/24 | Austin Reiter | C | signed One-year contract (through 2022) |
| 3/24 | Blake Bell | TE | re-signed/unrest FA One-year contract (through 2022) |
| 3/24 | Marquez Valdes-Scantling | WR | signed/unrest FA Three-year contract (through 2024) |
| 3/23 | Elijah Lee | LB | signed/unrest FA One-year contract (through 2022) |
| 3/22 | Derrick Nnadi | DT | re-signed/unrest FA One-year contract (through 2022) |
| 3/21 | JuJu Smith-Schuster | WR | signed/unrest FA One-year contract (through 2022) |
| 3/21 | Michael Burton | RB | re-signed/unrest FA One-year contract (through 2022) |
| 3/17 | Justin Reid | S | signed/unrest FA Three-year contract (through 2024) |
| 3/17 | Andrew Wylie | G | re-signed/unrest FA One-year contract (through 2022) |
| 3/16 | Chad Henne | QB | re-signed One-year contract (through 2022) |
| 3/16 | Charvarius Ward | CB | Declared Free Agent |
| 3/16 | Austin Blythe | G | Declared Free Agent |
| 3/16 | Blake Bell | TE | Declared Free Agent |
| 3/16 | Michael Burton | RB | Declared Free Agent |
| 3/16 | Mike Hughes | CB | Declared Free Agent |
| 3/16 | Melvin Ingram III | LB | Declared Free Agent |
| 3/16 | Marcus Kemp | WR | Declared Free Agent |
| 3/16 | Kyle Long | G | Declared Free Agent |
| 3/16 | Tyrann Mathieu | S | Declared Free Agent |
| 3/16 | Jerick McKinnon | RB | Declared Free Agent |
| 3/16 | Ben Niemann | LB | Declared Free Agent |
| 3/16 | Derrick Nnadi | DT | Declared Free Agent |
| 3/16 | Dorian O'Daniel | LB | Declared Free Agent |
| 3/16 | Alex Okafor | DE | Declared Free Agent |
| 3/16 | Byron Pringle | WR | Declared Free Agent |
| 3/16 | Jarran Reed | DT | Declared Free Agent |
| 3/16 | Mike Remmers | T | Declared Free Agent |
| 3/16 | Demarcus Robinson | WR | Declared Free Agent |
| 3/16 | Daniel Sorensen | S | Declared Free Agent |
| 3/16 | Armani Watts | S | Declared Free Agent |
| 3/16 | Darrel Williams | RB | Declared Free Agent |
| 3/16 | Andrew Wylie | G | Declared Free Agent |
| 3/16 | Chris Lammons | CB | Declared Free Agent |
| 3/8 | Orlando Brown Jr. | T | Designated franchise player non-exclusive franchise tag |
| 2/22 | Anthony Hitchens | LB | cut |
| 2/22 | Brandin Dandridge | CB | signed |
| 2/15 | Malik Herring | DE | reinstated |
Last updated Jan. 30, 1:07 A.M. ET
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