| Wednesday, 3 November 2021 |
| Time/Result | Home | Away | Venue |
| 0-0 |
Pachuca |
Atlético de San Luis | Estadio Hidalgo |
| 0-1 |
Cruz Azul |
León | Estadio Azteca |
| Thursday, 4 November 2021 |
| Time/Result | Home | Away | Venue |
| 0-3 |
Pumas |
Santos | Estadio Olimpico de Universitario |
| 2-0 |
Atlas |
Querétaro | Estadio Jalisco |
| Friday, 5 November 2021 |
| Time/Result | Home | Away | Venue |
| 1-0 |
Puebla |
Toluca | Estadio Cuauhtemoc |
| 0-1 |
Mazatlan |
Guadalajara | Estadio de Mazatlan |
| Saturday, 6 November 2021 |
| Time/Result | Home | Away | Venue |
| 3-0 |
León |
Necaxa | Estadio Leon (Nou Camp) |
| 0-0 |
América |
Monterrey | Estadio Azteca |
| 3-0 |
Tigres |
FC Juárez | Estadio Universitario de Nuevo Leon |
| 3-2 |
Tijuana |
Pachuca | Estadio Caliente |
| Sunday, 7 November 2021 |
| Time/Result | Home | Away | Venue |
| 4-3 |
Pumas |
Cruz Azul | Estadio Olimpico de Universitario |
| 0-0 |
Santos |
Atlético de San Luis | Estadio Nuevo Corona |
| Saturday, 20 November 2021 |
| Time/Result | Home | Away | Venue |
| 2-0 |
Santos |
Atlético de San Luis | Estadio Nuevo Corona |
| (6) 2-2 (5) |
Puebla |
Guadalajara | Estadio Cuauhtemoc |
| Sunday, 21 November 2021 |
| Time/Result | Home | Away | Venue |
| 1-2 |
Toluca |
Pumas | Estadio Nemesio Diez |
| 1-4 |
Cruz Azul |
Monterrey | Estadio Azteca |
| Wednesday, 24 November 2021 |
| Time/Result | Home | Away | Venue |
| 0-0 |
Pumas |
América | Estadio Olimpico de Universitario |
| 0-0 |
Monterrey |
Atlas | Estadio BBVA |
| Thursday, 25 November 2021 |
| Time/Result | Home | Away | Venue |
| 2-1 |
Puebla |
León | Estadio Cuauhtemoc |
| 2-1 |
Santos |
Tigres | Estadio Nuevo Corona |
| Saturday, 27 November 2021 |
| Time/Result | Home | Away | Venue |
| 1-3 |
América |
Pumas | Estadio Azteca |
| 1-1 |
Atlas |
Monterrey | Estadio Jalisco |
| Sunday, 28 November 2021 |
| Time/Result | Home | Away | Venue |
| 4:00 PM PT5:00 PM MT6:00 PM CT7:00 PM ET0:00 (+1) GMT1:00 0:00 12:00 AM 2:00 KSA11:00 AM AET5:30 (+1) IST7:30 PM VEN4:00 (+1) UAE8:00 AM SST8:00 7:00 5:00 PM MST6:00 PM CST7:00 PM EST19:00 ET19:00 20:00 BRT20:00 5:00 PM CT |
Tigres |
Santos | Estadio Universitario de Nuevo Leon |
| 6:05 PM PT7:05 PM MT8:05 PM CT9:05 PM ET2:05 (+1) GMT3:05 2:05 2:05 AM 4:05 KSA13:05 AM AET7:35 (+1) IST9:35 PM VEN6:05 (+1) UAE10:05 AM SST10:05 9:05 7:05 PM MST8:05 PM CST9:05 PM EST21:05 ET21:05 22:05 BRT22:05 7:05 PM CT |
León |
Puebla | Estadio Leon (Nou Camp) |
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