| Friday, 2 April 2021 |
| Time/Result | Home | Away | Venue |
| 3-1 |
Puebla |
Mazatlan | Estadio Cuauhtemoc |
| 0-1 |
FC Juárez |
Cruz Azul | Estadio Olimpico Benito Juarez |
| Saturday, 3 April 2021 |
| Time/Result | Home | Away | Venue |
| 1-0 |
Atlas |
Tijuana | Estadio Jalisco |
| 2-1 |
América |
Necaxa | Estadio Azteca |
| 2-0 |
Monterrey |
Atlético de San Luis | Estadio BBVA Bancomer |
| Sunday, 4 April 2021 |
| Time/Result | Home | Away | Venue |
| 2-2 |
Pumas |
Pachuca | Estadio Olimpico de Universitario |
| 1-1 |
Guadalajara |
Santos | Estadio AKRON |
| 0-1 |
Querétaro |
Tigres | Estadio La Corregidora |
| 2-1 |
León |
Toluca | Estadio Leon (Nou Camp) |
| Friday, 9 April 2021 |
| Time/Result | Home | Away | Venue |
| 0-1 |
Necaxa |
Pumas | Estadio Victoria de Aguascalientes |
| 2-1 |
FC Juárez |
Atlético de San Luis | Estadio Olimpico Benito Juarez |
| Saturday, 10 April 2021 |
| Time/Result | Home | Away | Venue |
| 1-3 |
Atlas |
León | Estadio Jalisco |
| 1-0 |
Cruz Azul |
Guadalajara | Estadio Azteca |
| 1-3 |
Tigres |
América | Estadio Universitario de Nuevo Leon |
| Sunday, 11 April 2021 |
| Time/Result | Home | Away | Venue |
| 1-2 |
Toluca |
Monterrey | Estadio Nemesio Diez |
| 1-0 |
Querétaro |
Santos | Estadio La Corregidora |
| 2-3 |
Tijuana |
Mazatlan | Estadio Caliente |
| Monday, 12 April 2021 |
| Time/Result | Home | Away | Venue |
| 1-3 |
Pachuca |
Puebla | Estadio Hidalgo |
| Wednesday, 14 April 2021 |
| Time/Result | Home | Away | Venue |
| 2-3 |
FC Juárez |
Tigres | Estadio Olimpico Benito Juarez |
| Friday, 16 April 2021 |
| Time/Result | Home | Away | Venue |
| 0-0 |
Necaxa |
Querétaro | Estadio Victoria de Aguascalientes |
| 0-0 |
Mazatlan |
Atlas | Estadio de Mazatlan |
| Saturday, 17 April 2021 |
| Time/Result | Home | Away | Venue |
| 1-4 |
Atlético de San Luis |
Puebla | Estadio Alfonso Lastras Ramirez |
| 2-0 |
Guadalajara |
Tijuana | Estadio AKRON |
| 1-1 |
América |
Cruz Azul | Estadio Azteca |
| Sunday, 18 April 2021 |
| Time/Result | Home | Away | Venue |
| 10:00 AM PT11:00 AM MT12:00 PM CT1:00 PM ET17:00 GMT18:00 17:00 5:00 PM 19:00 KSA4:00 AM AET22:30 IST12:30 PM VEN21:00 UAE1:00 AM SST1:00 0:00 10:00 AM MST11:00 AM CST12:00 PM EST13:00 ET12:00 14:00 BRT13:00 12:00 PM CT |
Pumas |
Tigres | Estadio Olimpico de Universitario |
| 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET0:00 (+1) GMT1:00 0:00 12:00 AM 2:00 KSA11:00 AM AET5:30 (+1) IST7:30 PM VEN4:00 (+1) UAE8:00 AM SST8:00 7:00 5:00 PM MST6:00 PM CST7:00 PM EST20:00 ET19:00 21:00 BRT20:00 7:00 PM CT |
Santos |
Toluca | Estadio Nuevo Corona |
| 7:06 PM PT8:06 PM MT9:06 PM CT10:06 PM ET2:06 (+1) GMT3:06 2:06 2:06 AM 4:06 KSA13:06 AM AET7:36 (+1) IST9:36 PM VEN6:06 (+1) UAE10:06 AM SST10:06 9:06 7:06 PM MST8:06 PM CST9:06 PM EST22:06 ET21:06 23:06 BRT22:06 9:06 PM CT |
Monterrey |
Pachuca | Estadio BBVA Bancomer |
| Monday, 19 April 2021 |
| Time/Result | Home | Away | Venue |
| 7:00 PM PT8:00 PM MT9:00 PM CT10:00 PM ET2:00 (+1) GMT3:00 2:00 2:00 AM 4:00 KSA13:00 AM AET7:30 (+1) IST9:30 PM VEN6:00 (+1) UAE10:00 AM SST10:00 9:00 7:00 PM MST8:00 PM CST9:00 PM EST22:00 ET21:00 23:00 BRT22:00 9:00 PM CT |
León |
FC Juárez | Estadio Leon (Nou Camp) |
| Wednesday, 21 April 2021 |
| Time/Result | Home | Away | Venue |
| 7:00 PM PT8:00 PM MT9:00 PM CT10:00 PM ET2:00 (+1) GMT3:00 2:00 2:00 AM 4:00 KSA13:00 AM AET7:30 (+1) IST9:30 PM VEN6:00 (+1) UAE10:00 AM SST10:00 9:00 7:00 PM MST8:00 PM CST9:00 PM EST22:00 ET21:00 23:00 BRT22:00 9:00 PM CT |
Monterrey |
Guadalajara | Estadio BBVA Bancomer |
| Friday, 23 April 2021 |
| Time/Result | Home | Away | Venue |
| 5:30 PM PT6:30 PM MT7:30 PM CT8:30 PM ET0:30 (+1) GMT1:30 0:30 12:30 AM 2:30 KSA11:30 AM AET6:00 (+1) IST8:00 PM VEN4:30 (+1) UAE8:30 AM SST8:30 7:30 5:30 PM MST6:30 PM CST7:30 PM EST20:30 ET19:30 21:30 BRT20:30 7:30 PM CT |
Puebla |
Pumas | Estadio Cuauhtemoc |
| 7:06 PM PT8:06 PM MT9:06 PM CT10:06 PM ET2:06 (+1) GMT3:06 2:06 2:06 AM 4:06 KSA13:06 AM AET7:36 (+1) IST9:36 PM VEN6:06 (+1) UAE10:06 AM SST10:06 9:06 7:06 PM MST8:06 PM CST9:06 PM EST22:06 ET21:06 23:06 BRT22:06 9:06 PM CT |
Tijuana |
Necaxa | Estadio Caliente |
| 7:30 PM PT8:30 PM MT9:30 PM CT10:30 PM ET2:30 (+1) GMT3:30 2:30 2:30 AM 4:30 KSA13:30 AM AET8:00 (+1) IST10:00 PM VEN6:30 (+1) UAE10:30 AM SST10:30 9:30 7:30 PM MST8:30 PM CST9:30 PM EST22:30 ET21:30 23:30 BRT22:30 9:30 PM CT |
Mazatlan |
León | Estadio de Mazatlan |
| Saturday, 24 April 2021 |
| Time/Result | Home | Away | Venue |
| 3:00 PM PT4:00 PM MT5:00 PM CT6:00 PM ET22:00 GMT23:00 22:00 10:00 PM 0:00 KSA9:00 AM AET3:30 (+1) IST5:30 PM VEN2:00 (+1) UAE6:00 AM SST6:00 5:00 3:00 PM MST4:00 PM CST5:00 PM EST18:00 ET17:00 19:00 BRT18:00 5:00 PM CT |
Cruz Azul |
Atlético de San Luis | Estadio Azteca |
| 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET0:00 (+1) GMT1:00 0:00 12:00 AM 2:00 KSA11:00 AM AET5:30 (+1) IST7:30 PM VEN4:00 (+1) UAE8:00 AM SST8:00 7:00 5:00 PM MST6:00 PM CST7:00 PM EST20:00 ET19:00 21:00 BRT20:00 7:00 PM CT |
Atlas |
Guadalajara | Estadio Jalisco |
| 7:00 PM PT8:00 PM MT9:00 PM CT10:00 PM ET2:00 (+1) GMT3:00 2:00 2:00 AM 4:00 KSA13:00 AM AET7:30 (+1) IST9:30 PM VEN6:00 (+1) UAE10:00 AM SST10:00 9:00 7:00 PM MST8:00 PM CST9:00 PM EST22:00 ET21:00 23:00 BRT22:00 9:00 PM CT |
Tigres |
Monterrey | Estadio Universitario de Nuevo Leon |
| Sunday, 25 April 2021 |
| Time/Result | Home | Away | Venue |
| 3:30 PM PT4:30 PM MT5:30 PM CT6:30 PM ET22:30 GMT23:30 22:30 10:30 PM 0:30 KSA9:30 AM AET4:00 (+1) IST6:00 PM VEN2:30 (+1) UAE6:30 AM SST6:30 5:30 3:30 PM MST4:30 PM CST5:30 PM EST18:30 ET17:30 19:30 BRT18:30 5:30 PM CT |
Toluca |
América | Estadio Nemesio Diez |
| 5:30 PM PT6:30 PM MT7:30 PM CT8:30 PM ET0:30 (+1) GMT1:30 0:30 12:30 AM 2:30 KSA11:30 AM AET6:00 (+1) IST8:00 PM VEN4:30 (+1) UAE8:30 AM SST8:30 7:30 5:30 PM MST6:30 PM CST7:30 PM EST20:30 ET19:30 21:30 BRT20:30 7:30 PM CT |
Querétaro |
FC Juárez | Estadio La Corregidora |
| Monday, 26 April 2021 |
| Time/Result | Home | Away | Venue |
| 7:00 PM PT8:00 PM MT9:00 PM CT10:00 PM ET2:00 (+1) GMT3:00 2:00 2:00 AM 4:00 KSA13:00 AM AET7:30 (+1) IST9:30 PM VEN6:00 (+1) UAE10:00 AM SST10:00 9:00 7:00 PM MST8:00 PM CST9:00 PM EST22:00 ET21:00 23:00 BRT22:00 9:00 PM CT |
Pachuca |
Santos | Estadio Hidalgo |
| Thursday, 29 April 2021 |
| Time/Result | Home | Away | Venue |
| 7:00 PM PT8:00 PM MT9:00 PM CT10:00 PM ET2:00 (+1) GMT3:00 2:00 2:00 AM 4:00 KSA13:00 AM AET7:30 (+1) IST9:30 PM VEN6:00 (+1) UAE10:00 AM SST10:00 9:00 7:00 PM MST8:00 PM CST9:00 PM EST22:00 ET21:00 23:00 BRT22:00 9:00 PM CT |
Atlético de San Luis |
Pachuca | Estadio Alfonso Lastras Ramirez |
| Friday, 30 April 2021 |
| Time/Result | Home | Away | Venue |
| 5:30 PM PT6:30 PM MT7:30 PM CT8:30 PM ET0:30 (+1) GMT1:30 0:30 12:30 AM 2:30 KSA11:30 AM AET6:00 (+1) IST8:00 PM VEN4:30 (+1) UAE8:30 AM SST8:30 7:30 5:30 PM MST6:30 PM CST7:30 PM EST20:30 ET19:30 21:30 BRT20:30 7:30 PM CT |
Necaxa |
Atlas | Estadio Victoria de Aguascalientes |
| 7:30 PM PT8:30 PM MT9:30 PM CT10:30 PM ET2:30 (+1) GMT3:30 2:30 2:30 AM 4:30 KSA13:30 AM AET8:00 (+1) IST10:00 PM VEN6:30 (+1) UAE10:30 AM SST10:30 9:30 7:30 PM MST8:30 PM CST9:30 PM EST22:30 ET21:30 23:30 BRT22:30 9:30 PM CT |
FC Juárez |
Toluca | Estadio Olimpico Benito Juarez |
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