| Friday, 1 October 2021 |
| Time/Result | Home | Away | Venue |
| 1-2 |
Puebla |
Pachuca | Estadio Cuauhtemoc |
| 3-1 |
FC Juárez |
Monterrey | Estadio Olimpico Benito Juarez |
| Saturday, 2 October 2021 |
| Time/Result | Home | Away | Venue |
| 0-0 |
León |
Atlético de San Luis | Estadio Leon (Nou Camp) |
| 1-0 |
Santos |
Mazatlan | Estadio Nuevo Corona |
| 0-1 |
Guadalajara |
Atlas | Estadio AKRON |
| Sunday, 3 October 2021 |
| Time/Result | Home | Away | Venue |
| 1-1 |
Toluca |
Querétaro | Estadio Nemesio Diez |
| 2-0 |
América |
Pumas | Estadio Azteca |
| 0-0 |
Tigres |
Necaxa | Estadio Universitario de Nuevo Leon |
| 0-1 |
Tijuana |
Cruz Azul | Estadio Caliente |
| Friday, 8 October 2021 |
| Time/Result | Home | Away | Venue |
| 0-0 |
FC Juárez |
Querétaro | Estadio Olimpico Benito Juarez |
| Thursday, 14 October 2021 |
| Time/Result | Home | Away | Venue |
| 1-1 |
Querétaro |
Tijuana | Estadio La Corregidora |
| Friday, 15 October 2021 |
| Time/Result | Home | Away | Venue |
| 0-1 |
Necaxa |
Puebla | Estadio Victoria de Aguascalientes |
| 1-0 |
Mazatlan |
Atlas | Estadio de Mazatlan |
| Saturday, 16 October 2021 |
| Time/Result | Home | Away | Venue |
| 0-1 |
Monterrey |
León | Estadio BBVA |
| 0-1 |
Atlético de San Luis |
América | Estadio Alfonso Lastras Ramirez |
| 1-1 |
Pachuca |
Santos | Estadio Hidalgo |
| 1-1 |
Cruz Azul |
Tigres | Estadio Azteca |
| Sunday, 17 October 2021 |
| Time/Result | Home | Away | Venue |
| 1-0 |
Pumas |
FC Juárez | Estadio Olimpico de Universitario |
| 2-0 |
Guadalajara |
Toluca | Estadio AKRON |
| Tuesday, 19 October 2021 |
| Time/Result | Home | Away | Venue |
| 1-0 |
Querétaro |
Monterrey | Estadio La Corregidora |
| 2-0 |
Puebla |
Mazatlan | Estadio Cuauhtemoc |
| 2-1 |
América |
Santos | Estadio Azteca |
| 0-0 |
Atlas |
Cruz Azul | Estadio Jalisco |
| Wednesday, 20 October 2021 |
| Time/Result | Home | Away | Venue |
| 1-2 |
León |
Pumas | Estadio Leon (Nou Camp) |
| 1-1 |
Toluca |
Necaxa | Estadio Nemesio Diez |
| 3-0 |
Tigres |
Pachuca | Estadio Universitario de Nuevo Leon |
| 0-0 |
Tijuana |
Guadalajara | Estadio Caliente |
| Friday, 22 October 2021 |
| Time/Result | Home | Away | Venue |
| 2-1 |
Mazatlan |
Querétaro | Estadio de Mazatlan |
| Saturday, 23 October 2021 |
| Time/Result | Home | Away | Venue |
| 3:00 PM PT4:00 PM MT5:00 PM CT6:00 PM ET22:00 GMT23:00 22:00 10:00 PM 0:00 KSA9:00 AM AET3:30 (+1) IST5:30 PM VEN2:00 (+1) UAE6:00 AM SST6:00 5:00 3:00 PM MST4:00 PM CST5:00 PM EST18:00 ET17:00 19:00 BRT18:00 5:00 PM CT |
Puebla |
León | Estadio Cuauhtemoc |
| 3:06 PM PT4:06 PM MT5:06 PM CT6:06 PM ET22:06 GMT23:06 22:06 10:06 PM 0:06 KSA9:06 AM AET3:36 (+1) IST5:36 PM VEN2:06 (+1) UAE6:06 AM SST6:06 5:06 3:06 PM MST4:06 PM CST5:06 PM EST18:06 ET17:06 19:06 BRT18:06 5:06 PM CT |
Monterrey |
Necaxa | Estadio BBVA |
| 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET0:00 (+1) GMT1:00 0:00 12:00 AM 2:00 KSA11:00 AM AET5:30 (+1) IST7:30 PM VEN4:00 (+1) UAE8:00 AM SST8:00 7:00 5:00 PM MST6:00 PM CST7:00 PM EST20:00 ET19:00 21:00 BRT20:00 7:00 PM CT |
América |
Tigres | Estadio Azteca |
| 7:00 PM PT8:00 PM MT9:00 PM CT10:00 PM ET2:00 (+1) GMT3:00 2:00 2:00 AM 4:00 KSA13:00 AM AET7:30 (+1) IST9:30 PM VEN6:00 (+1) UAE10:00 AM SST10:00 9:00 7:00 PM MST8:00 PM CST9:00 PM EST22:00 ET21:00 23:00 BRT22:00 9:00 PM CT |
Guadalajara |
Cruz Azul | Estadio AKRON |
| Sunday, 24 October 2021 |
| Time/Result | Home | Away | Venue |
| 10:00 AM PT11:00 AM MT12:00 PM CT1:00 PM ET17:00 GMT18:00 17:00 5:00 PM 19:00 KSA4:00 AM AET22:30 IST12:30 PM VEN21:00 UAE1:00 AM SST1:00 0:00 10:00 AM MST11:00 AM CST12:00 PM EST13:00 ET12:00 14:00 BRT13:00 12:00 PM CT |
Pumas |
Tijuana | Estadio Olimpico de Universitario |
| 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET0:00 (+1) GMT1:00 0:00 12:00 AM 2:00 KSA11:00 AM AET5:30 (+1) IST7:30 PM VEN4:00 (+1) UAE8:00 AM SST8:00 7:00 5:00 PM MST6:00 PM CST7:00 PM EST20:00 ET19:00 21:00 BRT20:00 7:00 PM CT |
Atlético de San Luis |
Atlas | Estadio Alfonso Lastras Ramirez |
| 5:06 PM PT6:06 PM MT7:06 PM CT8:06 PM ET0:06 (+1) GMT1:06 0:06 12:06 AM 2:06 KSA11:06 AM AET5:36 (+1) IST7:36 PM VEN4:06 (+1) UAE8:06 AM SST8:06 7:06 5:06 PM MST6:06 PM CST7:06 PM EST20:06 ET19:06 21:06 BRT20:06 7:06 PM CT |
Santos |
Toluca | Estadio Nuevo Corona |
| 7:00 PM PT8:00 PM MT9:00 PM CT10:00 PM ET2:00 (+1) GMT3:00 2:00 2:00 AM 4:00 KSA13:00 AM AET7:30 (+1) IST9:30 PM VEN6:00 (+1) UAE10:00 AM SST10:00 9:00 7:00 PM MST8:00 PM CST9:00 PM EST22:00 ET21:00 23:00 BRT22:00 9:00 PM CT |
Pachuca |
FC Juárez | Estadio Hidalgo |
| Thursday, 28 October 2021 |
| Time/Result | Home | Away | Venue |
| 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET0:00 (+1) GMT1:00 0:00 12:00 AM 2:00 KSA11:00 AM AET5:30 (+1) IST7:30 PM VEN4:00 (+1) UAE8:00 AM SST8:00 7:00 5:00 PM MST6:00 PM CST7:00 PM EST20:00 ET19:00 21:00 BRT20:00 7:00 PM CT |
Atlas |
Tijuana | Estadio Jalisco |
| Friday, 29 October 2021 |
| Time/Result | Home | Away | Venue |
| 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET0:00 (+1) GMT1:00 0:00 12:00 AM 2:00 KSA11:00 AM AET5:30 (+1) IST7:30 PM VEN4:00 (+1) UAE8:00 AM SST8:00 7:00 5:00 PM MST6:00 PM CST7:00 PM EST20:00 ET19:00 21:00 BRT20:00 7:00 PM CT |
Necaxa |
Mazatlan | Estadio Victoria de Aguascalientes |
| 7:00 PM PT8:00 PM MT9:00 PM CT10:00 PM ET2:00 (+1) GMT3:00 2:00 2:00 AM 4:00 KSA13:00 AM AET7:30 (+1) IST9:30 PM VEN6:00 (+1) UAE10:00 AM SST10:00 9:00 7:00 PM MST8:00 PM CST9:00 PM EST22:00 ET21:00 23:00 BRT22:00 9:00 PM CT |
FC Juárez |
Puebla | Estadio Olimpico Benito Juarez |
| Saturday, 30 October 2021 |
| Time/Result | Home | Away | Venue |
| 3:00 PM PT4:00 PM MT5:00 PM CT6:00 PM ET22:00 GMT23:00 22:00 10:00 PM 0:00 KSA9:00 AM AET3:30 (+1) IST5:30 PM VEN2:00 (+1) UAE6:00 AM SST6:00 5:00 3:00 PM MST4:00 PM CST5:00 PM EST18:00 ET17:00 19:00 BRT18:00 5:00 PM CT |
Querétaro |
Santos | Estadio La Corregidora |
| 6:06 PM PT7:06 PM MT8:06 PM CT9:06 PM ET1:06 (+1) GMT2:06 1:06 1:06 AM 3:06 KSA12:06 AM AET6:36 (+1) IST8:36 PM VEN5:06 (+1) UAE9:06 AM SST9:06 8:06 6:06 PM MST7:06 PM CST8:06 PM EST21:06 ET20:06 22:06 BRT21:06 8:06 PM CT |
Pachuca |
Pumas | Estadio Hidalgo |
| 7:00 PM PT8:00 PM MT9:00 PM CT10:00 PM ET2:00 (+1) GMT3:00 2:00 2:00 AM 4:00 KSA13:00 AM AET7:30 (+1) IST9:30 PM VEN6:00 (+1) UAE10:00 AM SST10:00 9:00 7:00 PM MST8:00 PM CST9:00 PM EST22:00 ET21:00 23:00 BRT22:00 9:00 PM CT |
Tigres |
Guadalajara | Estadio Universitario de Nuevo Leon |
| Sunday, 31 October 2021 |
| Time/Result | Home | Away | Venue |
| 11:00 AM PT12:00 PM MT1:00 PM CT2:00 PM ET18:00 GMT19:00 18:00 6:00 PM 20:00 KSA5:00 AM AET23:30 IST1:30 PM VEN22:00 UAE2:00 AM SST2:00 1:00 11:00 AM MST12:00 PM CST1:00 PM EST14:00 ET13:00 15:00 BRT14:00 1:00 PM CT |
Toluca |
León | Estadio Nemesio Diez |
| 4:05 PM PT5:05 PM MT6:05 PM CT7:05 PM ET23:05 GMT0:05 23:05 11:05 PM 1:05 KSA10:05 AM AET4:35 (+1) IST6:35 PM VEN3:05 (+1) UAE7:05 AM SST7:05 6:05 4:05 PM MST5:05 PM CST6:05 PM EST19:05 ET18:05 20:05 BRT19:05 6:05 PM CT |
Cruz Azul |
América | Estadio Azteca |
| 6:05 PM PT7:05 PM MT8:05 PM CT9:05 PM ET1:05 (+1) GMT2:05 1:05 1:05 AM 3:05 KSA12:05 AM AET6:35 (+1) IST8:35 PM VEN5:05 (+1) UAE9:05 AM SST9:05 8:05 6:05 PM MST7:05 PM CST8:05 PM EST21:05 ET20:05 22:05 BRT21:05 8:05 PM CT |
Atlético de San Luis |
Monterrey | Estadio Alfonso Lastras Ramirez |
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