| July 2021 |
| Date | Time | Opponent | Venue | Result |
| Sun. 25 | 7:06 PM PT8:06 PM MT9:06 PM CT10:06 PM ET2:06 (+1) GMT3:06 2:06 2:06 AM 4:06 KSA13:06 AM AET7:36 (+1) IST9:36 PM VEN6:06 (+1) UAE10:06 AM SST10:06 9:06 7:06 PM MST8:06 PM CST9:06 PM EST22:06 ET21:06 23:06 BRT22:06 9:06 PM CT | Tijuana | Estadio Caliente | W 2-1 |
| August 2021 |
| Date | Time | Opponent | Venue | Result |
| Sun. 1 | 10:00 AM PT11:00 AM MT12:00 PM CT1:00 PM ET17:00 GMT18:00 17:00 5:00 PM 19:00 KSA4:00 AM AET22:30 IST12:30 PM VEN21:00 UAE1:00 AM SST1:00 0:00 10:00 AM MST11:00 AM CST12:00 PM EST13:00 ET12:00 14:00 BRT13:00 12:00 PM CT | Toluca | Estadio Nemesio Diez | L 1-3 |
| Sat. 7 | 7:00 PM PT8:00 PM MT9:00 PM CT10:00 PM ET2:00 (+1) GMT3:00 2:00 2:00 AM 4:00 KSA13:00 AM AET7:30 (+1) IST9:30 PM VEN6:00 (+1) UAE10:00 AM SST10:00 9:00 7:00 PM MST8:00 PM CST9:00 PM EST22:00 ET21:00 23:00 BRT22:00 9:00 PM CT | Santos | Estadio Universitario de Nuevo Leon | D 1-1 |
| Fri. 13 | 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET0:00 (+1) GMT1:00 0:00 12:00 AM 2:00 KSA11:00 AM AET5:30 (+1) IST7:30 PM VEN4:00 (+1) UAE8:00 AM SST8:00 7:00 5:00 PM MST6:00 PM CST7:00 PM EST20:00 ET19:00 21:00 BRT20:00 7:00 PM CT | Puebla | Estadio Cuauhtemoc | D 1-1 |
| Tue. 17 | 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET0:00 (+1) GMT1:00 0:00 12:00 AM 2:00 KSA11:00 AM AET5:30 (+1) IST7:30 PM VEN4:00 (+1) UAE8:00 AM SST8:00 7:00 5:00 PM MST6:00 PM CST7:00 PM EST20:00 ET19:00 21:00 BRT20:00 7:00 PM CT | Querétaro | Estadio Universitario de Nuevo Leon | W 3-0 |
| Fri. 20 | 7:00 PM PT8:00 PM MT9:00 PM CT10:00 PM ET2:00 (+1) GMT3:00 2:00 2:00 AM 4:00 KSA13:00 AM AET7:30 (+1) IST9:30 PM VEN6:00 (+1) UAE10:00 AM SST10:00 9:00 7:00 PM MST8:00 PM CST9:00 PM EST22:00 ET21:00 23:00 BRT22:00 9:00 PM CT | Mazatlan | Estadio de Mazatlan | W 3-0 |
| Sat. 28 | 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET0:00 (+1) GMT1:00 0:00 12:00 AM 2:00 KSA11:00 AM AET5:30 (+1) IST7:30 PM VEN4:00 (+1) UAE8:00 AM SST8:00 7:00 5:00 PM MST6:00 PM CST7:00 PM EST20:00 ET19:00 21:00 BRT20:00 7:00 PM CT | Atlas | Estadio Universitario de Nuevo Leon | D 1-1 |
| September 2021 |
| Date | Time | Opponent | Venue | Result |
| Sat. 11 | 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET0:00 (+1) GMT1:00 0:00 12:00 AM 2:00 KSA11:00 AM AET5:30 (+1) IST7:30 PM VEN4:00 (+1) UAE8:00 AM SST8:00 7:00 5:00 PM MST6:00 PM CST7:00 PM EST20:00 ET19:00 21:00 BRT20:00 7:00 PM CT | León | Estadio Universitario de Nuevo Leon | D 2-2 |
| Sun. 19 | 5:06 PM PT6:06 PM MT7:06 PM CT8:06 PM ET0:06 (+1) GMT1:06 0:06 12:06 AM 2:06 KSA11:06 AM AET5:36 (+1) IST7:36 PM VEN4:06 (+1) UAE8:06 AM SST8:06 7:06 5:06 PM MST6:06 PM CST7:06 PM EST20:06 ET19:06 21:06 BRT20:06 7:06 PM CT | Monterrey | Estadio BBVA | L 0-2 |
| Sat. 25 | 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET0:00 (+1) GMT1:00 0:00 12:00 AM 2:00 KSA11:00 AM AET5:30 (+1) IST7:30 PM VEN4:00 (+1) UAE8:00 AM SST8:00 7:00 5:00 PM MST6:00 PM CST7:00 PM EST20:00 ET19:00 21:00 BRT20:00 7:00 PM CT | Pumas | Estadio Universitario de Nuevo Leon | D 0-0 |
| Wed. 29 | 3:00 PM PT4:00 PM MT5:00 PM CT6:00 PM ET22:00 GMT23:00 22:00 10:00 PM 0:00 KSA9:00 AM AET3:30 (+1) IST5:30 PM VEN2:00 (+1) UAE6:00 AM SST6:00 5:00 3:00 PM MST4:00 PM CST5:00 PM EST18:00 ET17:00 19:00 BRT18:00 5:00 PM CT | Atlético de San Luis | Estadio Alfonso Lastras Ramirez | W 3-0 |
| October 2021 |
| Date | Time | Opponent | Venue | Result |
| Sun. 3 | 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET0:00 (+1) GMT1:00 0:00 12:00 AM 2:00 KSA11:00 AM AET5:30 (+1) IST7:30 PM VEN4:00 (+1) UAE8:00 AM SST8:00 7:00 5:00 PM MST6:00 PM CST7:00 PM EST20:00 ET19:00 21:00 BRT20:00 7:00 PM CT | Necaxa | Estadio Universitario de Nuevo Leon | D 0-0 |
| Sat. 16 | 7:00 PM PT8:00 PM MT9:00 PM CT10:00 PM ET2:00 (+1) GMT3:00 2:00 2:00 AM 4:00 KSA13:00 AM AET7:30 (+1) IST9:30 PM VEN6:00 (+1) UAE10:00 AM SST10:00 9:00 7:00 PM MST8:00 PM CST9:00 PM EST22:00 ET21:00 23:00 BRT22:00 9:00 PM CT | Cruz Azul | Estadio Azteca | D 1-1 |
| Wed. 20 | 7:00 PM PT8:00 PM MT9:00 PM CT10:00 PM ET2:00 (+1) GMT3:00 2:00 2:00 AM 4:00 KSA13:00 AM AET7:30 (+1) IST9:30 PM VEN6:00 (+1) UAE10:00 AM SST10:00 9:00 7:00 PM MST8:00 PM CST9:00 PM EST22:00 ET21:00 23:00 BRT22:00 9:00 PM CT | Pachuca | Estadio Universitario de Nuevo Leon | W 3-0 |
| Sat. 23 | 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET0:00 (+1) GMT1:00 0:00 12:00 AM 2:00 KSA11:00 AM AET5:30 (+1) IST7:30 PM VEN4:00 (+1) UAE8:00 AM SST8:00 7:00 5:00 PM MST6:00 PM CST7:00 PM EST20:00 ET19:00 21:00 BRT20:00 7:00 PM CT | América | Estadio Azteca | L 0-1 |
| Sat. 30 | 7:10 PM PT8:10 PM MT9:10 PM CT10:10 PM ET2:10 (+1) GMT3:10 2:10 2:10 AM 4:10 KSA13:10 AM AET7:40 (+1) IST9:40 PM VEN6:10 (+1) UAE10:10 AM SST10:10 9:10 7:10 PM MST8:10 PM CST9:10 PM EST22:10 ET21:10 23:10 BRT22:10 9:10 PM CT | Guadalajara | Estadio Universitario de Nuevo Leon | W 2-1 |
| November 2021 |
| Date | Time | Opponent | Venue | Result |
| Sat. 6 | 8:00 PM PT9:00 PM MT10:00 PM CT11:00 PM ET3:00 (+1) GMT4:00 3:00 3:00 AM 5:00 KSA14:00 AM AET8:30 (+1) IST10:30 PM VEN7:00 (+1) UAE11:00 AM SST11:00 10:00 8:00 PM MST9:00 PM CST10:00 PM EST23:00 ET22:00 0:00 BRT23:00 9:00 PM CT | FC Juárez | Estadio Universitario de Nuevo Leon | W 3-0 |
| Thu. 25 | 7:05 PM PT8:05 PM MT9:05 PM CT10:05 PM ET3:05 (+1) GMT4:05 3:05 3:05 AM 5:05 KSA14:05 AM AET8:35 (+1) IST10:35 PM VEN7:05 (+1) UAE11:05 AM SST11:05 10:05 8:05 PM MST9:05 PM CST10:05 PM EST22:05 ET22:05 23:05 BRT23:05 8:05 PM CT | Santos | Estadio Nuevo Corona | L 1-2 |
| Sun. 28 | 4:00 PM PT5:00 PM MT6:00 PM CT7:00 PM ET0:00 (+1) GMT1:00 0:00 12:00 AM 2:00 KSA11:00 AM AET5:30 (+1) IST7:30 PM VEN4:00 (+1) UAE8:00 AM SST8:00 7:00 5:00 PM MST6:00 PM CST7:00 PM EST19:00 ET19:00 20:00 BRT20:00 5:00 PM CT | Santos | Estadio Universitario de Nuevo Leon | |
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