| July 2022 |
| Date | Time | Opponent | Venue | Result |
| Sat. 2 | 5:05 PM PT6:05 PM MT7:05 PM CT8:05 PM ET0:05 (+1) GMT1:05 0:05 12:05 AM 2:05 KSA11:05 AM AET5:35 (+1) IST7:35 PM VEN4:05 (+1) UAE8:05 AM SST8:05 7:05 5:05 PM MST6:05 PM CST7:05 PM EST20:05 ET19:05 21:05 BRT20:05 7:05 PM CT | Cruz Azul | Estadio Universitario de Nuevo Leon | L 2-3 |
| Fri. 8 | 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET0:00 (+1) GMT1:00 0:00 12:00 AM 2:00 KSA11:00 AM AET5:30 (+1) IST7:30 PM VEN4:00 (+1) UAE8:00 AM SST8:00 7:00 5:00 PM MST6:00 PM CST7:00 PM EST20:00 ET19:00 21:00 BRT20:00 7:00 PM CT | Mazatlan | Estadio de Mazatlan | W 1-0 |
| Sun. 17 | 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET0:00 (+1) GMT1:00 0:00 12:00 AM 2:00 KSA11:00 AM AET5:30 (+1) IST7:30 PM VEN4:00 (+1) UAE8:00 AM SST8:00 7:00 5:00 PM MST6:00 PM CST7:00 PM EST20:00 ET19:00 21:00 BRT20:00 7:00 PM CT | Tijuana | Estadio Universitario de Nuevo Leon | W 1-0 |
| Sat. 23 | 7:05 PM PT8:05 PM MT9:05 PM CT10:05 PM ET2:05 (+1) GMT3:05 2:05 2:05 AM 4:05 KSA13:05 AM AET7:35 (+1) IST9:35 PM VEN6:05 (+1) UAE10:05 AM SST10:05 9:05 7:05 PM MST8:05 PM CST9:05 PM EST22:05 ET21:05 23:05 BRT22:05 9:05 PM CT | Atlas | Estadio Universitario de Nuevo Leon | W 2-0 |
| Tue. 26 | 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET0:00 (+1) GMT1:00 0:00 12:00 AM 2:00 KSA11:00 AM AET5:30 (+1) IST7:30 PM VEN4:00 (+1) UAE8:00 AM SST8:00 7:00 5:00 PM MST6:00 PM CST7:00 PM EST20:00 ET19:00 21:00 BRT20:00 7:00 PM CT | Juarez | Estadio Olimpico Benito Juarez | W 1-0 |
| Sat. 30 | 5:05 PM PT6:05 PM MT7:05 PM CT8:05 PM ET0:05 (+1) GMT1:05 0:05 12:05 AM 2:05 KSA11:05 AM AET5:35 (+1) IST7:35 PM VEN4:05 (+1) UAE8:05 AM SST8:05 7:05 5:05 PM MST6:05 PM CST7:05 PM EST20:05 ET19:05 21:05 BRT20:05 7:05 PM CT | Queretaro | Estadio Universitario de Nuevo Leon | W 2-1 |
| August 2022 |
| Date | Time | Opponent | Venue | Result |
| Sun. 7 | 4:05 PM PT5:05 PM MT6:05 PM CT7:05 PM ET23:05 GMT0:05 23:05 11:05 PM 1:05 KSA10:05 AM AET4:35 (+1) IST6:35 PM VEN3:05 (+1) UAE7:05 AM SST7:05 6:05 4:05 PM MST5:05 PM CST6:05 PM EST19:05 ET18:05 20:05 BRT19:05 6:05 PM CT | Pachuca | Estadio Hidalgo | L 0-2 |
| Sun. 14 | 5:05 PM PT6:05 PM MT7:05 PM CT8:05 PM ET0:05 (+1) GMT1:05 0:05 12:05 AM 2:05 KSA11:05 AM AET5:35 (+1) IST7:35 PM VEN4:05 (+1) UAE8:05 AM SST8:05 7:05 5:05 PM MST6:05 PM CST7:05 PM EST20:05 ET19:05 21:05 BRT20:05 7:05 PM CT | Santos Laguna | Estadio Universitario de Nuevo Leon | W 2-0 |
| Sat. 20 | 5:05 PM PT6:05 PM MT7:05 PM CT8:05 PM ET0:05 (+1) GMT1:05 0:05 12:05 AM 2:05 KSA11:05 AM AET5:35 (+1) IST7:35 PM VEN4:05 (+1) UAE8:05 AM SST8:05 7:05 5:05 PM MST6:05 PM CST7:05 PM EST20:05 ET19:05 21:05 BRT20:05 7:05 PM CT | Monterrey | Estadio BBVA | D 0-0 |
| Wed. 24 | 7:05 PM PT8:05 PM MT9:05 PM CT10:05 PM ET2:05 (+1) GMT3:05 2:05 2:05 AM 4:05 KSA13:05 AM AET7:35 (+1) IST9:35 PM VEN6:05 (+1) UAE10:05 AM SST10:05 9:05 7:05 PM MST8:05 PM CST9:05 PM EST22:05 ET21:05 23:05 BRT22:05 9:05 PM CT | Pumas UNAM | Estadio Olimpico de Universitario | D 1-1 |
| Sat. 27 | 5:05 PM PT6:05 PM MT7:05 PM CT8:05 PM ET0:05 (+1) GMT1:05 0:05 12:05 AM 2:05 KSA11:05 AM AET5:35 (+1) IST7:35 PM VEN4:05 (+1) UAE8:05 AM SST8:05 7:05 5:05 PM MST6:05 PM CST7:05 PM EST20:05 ET19:05 21:05 BRT20:05 7:05 PM CT | Necaxa | Estadio Universitario de Nuevo Leon | D 0-0 |
| September 2022 |
| Date | Time | Opponent | Venue | Result |
| Sat. 3 | 7:05 PM PT8:05 PM MT9:05 PM CT10:05 PM ET2:05 (+1) GMT3:05 2:05 2:05 AM 4:05 KSA13:05 AM AET7:35 (+1) IST9:35 PM VEN6:05 (+1) UAE10:05 AM SST10:05 9:05 7:05 PM MST8:05 PM CST9:05 PM EST22:05 ET21:05 23:05 BRT22:05 9:05 PM CT | America | Estadio Azteca | L 1-2 |
| Wed. 7 | 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET0:00 (+1) GMT1:00 0:00 12:00 AM 2:00 KSA11:00 AM AET5:30 (+1) IST7:30 PM VEN4:00 (+1) UAE8:00 AM SST8:00 7:00 5:00 PM MST6:00 PM CST7:00 PM EST20:00 ET19:00 21:00 BRT20:00 7:00 PM CT | Toluca | Estadio Universitario de Nuevo Leon | W 3-1 |
| Sat. 10 | 5:05 PM PT6:05 PM MT7:05 PM CT8:05 PM ET0:05 (+1) GMT1:05 0:05 12:05 AM 2:05 KSA11:05 AM AET5:35 (+1) IST7:35 PM VEN4:05 (+1) UAE8:05 AM SST8:05 7:05 5:05 PM MST6:05 PM CST7:05 PM EST20:05 ET19:05 21:05 BRT20:05 7:05 PM CT | Leon | Estadio Universitario de Nuevo Leon | L 0-1 |
| Tue. 13 | 7:05 PM PT8:05 PM MT9:05 PM CT10:05 PM ET2:05 (+1) GMT3:05 2:05 2:05 AM 4:05 KSA13:05 AM AET7:35 (+1) IST9:35 PM VEN6:05 (+1) UAE10:05 AM SST10:05 9:05 7:05 PM MST8:05 PM CST9:05 PM EST22:05 ET21:05 23:05 BRT22:05 9:05 PM CT | Guadalajara | Estadio AKRON | W 4-1 |
| Fri. 16 | 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET0:00 (+1) GMT1:00 0:00 12:00 AM 2:00 KSA11:00 AM AET5:30 (+1) IST7:30 PM VEN4:00 (+1) UAE8:00 AM SST8:00 7:00 5:00 PM MST6:00 PM CST7:00 PM EST20:00 ET19:00 21:00 BRT20:00 7:00 PM CT | Puebla | Estadio Cuauhtemoc | L 1-2 |
| October 2022 |
| Date | Time | Opponent | Venue | Result |
| Sat. 1 | 3:00 PM PT4:00 PM MT5:00 PM CT6:00 PM ET22:00 GMT23:00 22:00 10:00 PM 0:00 KSA9:00 AM AET3:30 (+1) IST5:30 PM VEN2:00 (+1) UAE6:00 AM SST6:00 5:00 3:00 PM MST4:00 PM CST5:00 PM EST18:00 ET17:00 19:00 BRT18:00 5:00 PM CT | Atletico San Luis | Estadio Alfonso Lastras Ramirez | |
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