| January 2022 |
| Date | Time | Opponent | Venue | Result |
| Wed. 12 | 6:06 PM PT7:06 PM MT8:06 PM CT9:06 PM ET2:06 (+1) GMT3:06 2:06 2:06 AM 4:06 KSA13:06 AM AET7:36 (+1) IST9:36 PM VEN6:06 (+1) UAE10:06 AM SST10:06 9:06 7:06 PM MST8:06 PM CST9:06 PM EST21:06 ET21:06 22:06 BRT22:06 7:06 PM CT | Santos | Estadio Nuevo Corona | D 1-1 |
| Sat. 15 | 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET1:00 (+1) GMT2:00 1:00 1:00 AM 3:00 KSA12:00 AM AET6:30 (+1) IST8:30 PM VEN5:00 (+1) UAE9:00 AM SST9:00 8:00 6:00 PM MST7:00 PM CST8:00 PM EST20:00 ET20:00 21:00 BRT21:00 6:00 PM CT | Puebla | Estadio Universitario de Nuevo Leon | L 0-2 |
| Sun. 23 | 10:00 AM PT11:00 AM MT12:00 PM CT1:00 PM ET18:00 GMT19:00 18:00 6:00 PM 20:00 KSA5:00 AM AET23:30 IST1:30 PM VEN22:00 UAE2:00 AM SST2:00 1:00 11:00 AM MST12:00 PM CST1:00 PM EST13:00 ET13:00 14:00 BRT14:00 11:00 AM CT | Pumas | Estadio Olimpico de Universitario | W 2-1 |
| February 2022 |
| Date | Time | Opponent | Venue | Result |
| Sun. 6 | 6:00 PM PT7:00 PM MT8:00 PM CT9:00 PM ET2:00 (+1) GMT3:00 2:00 2:00 AM 4:00 KSA13:00 AM AET7:30 (+1) IST9:30 PM VEN6:00 (+1) UAE10:00 AM SST10:00 9:00 7:00 PM MST8:00 PM CST9:00 PM EST21:00 ET21:00 22:00 BRT22:00 7:00 PM CT | Mazatlan | Estadio Universitario de Nuevo Leon | W 4-3 |
| Sat. 12 | 3:00 PM PT4:00 PM MT5:00 PM CT6:00 PM ET23:00 GMT0:00 23:00 11:00 PM 1:00 KSA10:00 AM AET4:30 (+1) IST6:30 PM VEN3:00 (+1) UAE7:00 AM SST7:00 6:00 4:00 PM MST5:00 PM CST6:00 PM EST18:00 ET18:00 19:00 BRT19:00 4:00 PM CT | Guadalajara | Estadio AKRON | W 3-1 |
| Sat. 19 | 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET1:00 (+1) GMT2:00 1:00 1:00 AM 3:00 KSA12:00 AM AET6:30 (+1) IST8:30 PM VEN5:00 (+1) UAE9:00 AM SST9:00 8:00 6:00 PM MST7:00 PM CST8:00 PM EST20:00 ET20:00 21:00 BRT21:00 6:00 PM CT | Atlético de San Luis | Estadio Universitario de Nuevo Leon | W 2-1 |
| Fri. 25 | 7:00 PM PT8:00 PM MT9:00 PM CT10:00 PM ET3:00 (+1) GMT4:00 3:00 3:00 AM 5:00 KSA14:00 AM AET8:30 (+1) IST10:30 PM VEN7:00 (+1) UAE11:00 AM SST11:00 10:00 8:00 PM MST9:00 PM CST10:00 PM EST22:00 ET22:00 0:00 BRT23:00 8:00 PM CT | FC Juárez | Estadio Olimpico Benito Juarez | W 3-2 |
| March 2022 |
| Date | Time | Opponent | Venue | Result |
| Wed. 2 | 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET1:00 (+1) GMT2:00 1:00 1:00 AM 3:00 KSA12:00 AM AET6:30 (+1) IST8:30 PM VEN5:00 (+1) UAE9:00 AM SST9:00 8:00 6:00 PM MST7:00 PM CST8:00 PM EST20:00 ET20:00 22:00 BRT21:00 6:00 PM CT | Cruz Azul | Estadio Universitario de Nuevo Leon | D 2-2 |
| Sun. 6 | 4:00 PM PT5:00 PM MT6:00 PM CT7:00 PM ET0:00 (+1) GMT1:00 0:00 12:00 AM 2:00 KSA11:00 AM AET5:30 (+1) IST7:30 PM VEN4:00 (+1) UAE8:00 AM SST8:00 7:00 5:00 PM MST6:00 PM CST7:00 PM EST19:00 ET19:00 21:00 BRT20:00 5:00 PM CT | Pachuca | Estadio Hidalgo | Postponed |
| Sat. 12 | 3:00 PM PT4:00 PM MT5:00 PM CT6:00 PM ET23:00 GMT0:00 23:00 11:00 PM 1:00 KSA10:00 AM AET4:30 (+1) IST6:30 PM VEN3:00 (+1) UAE7:00 AM SST7:00 6:00 4:00 PM MST5:00 PM CST6:00 PM EST18:00 ET18:00 20:00 BRT19:00 4:00 PM CT | León | Estadio Leon (Nou Camp) | W 3-0 |
| Sat. 19 | 6:00 PM PT7:00 PM MT8:00 PM CT9:00 PM ET1:00 (+1) GMT2:00 1:00 1:00 AM 3:00 KSA12:00 AM AET6:30 (+1) IST8:30 PM VEN5:00 (+1) UAE9:00 AM SST9:00 8:00 6:00 PM MST7:00 PM CST8:00 PM EST21:00 ET20:00 22:00 BRT21:00 7:00 PM CT | Monterrey | Estadio Universitario de Nuevo Leon | W 2-0 |
| April 2022 |
| Date | Time | Opponent | Venue | Result |
| Sun. 3 | 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET0:00 (+1) GMT1:00 0:00 12:00 AM 2:00 KSA11:00 AM AET5:30 (+1) IST7:30 PM VEN4:00 (+1) UAE8:00 AM SST8:00 7:00 5:00 PM MST6:00 PM CST7:00 PM EST20:00 ET19:00 21:00 BRT20:00 7:00 PM CT | Tijuana | Estadio Universitario de Nuevo Leon | W 2-0 |
| Thu. 7 | 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET0:00 (+1) GMT1:00 0:00 12:00 AM 2:00 KSA11:00 AM AET5:30 (+1) IST7:30 PM VEN4:00 (+1) UAE8:00 AM SST8:00 7:00 5:00 PM MST6:00 PM CST7:00 PM EST20:00 ET19:00 21:00 BRT20:00 7:00 PM CT | Pachuca | Estadio Hidalgo | L 1-2 |
| Sun. 10 | 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET0:00 (+1) GMT1:00 0:00 12:00 AM 2:00 KSA11:00 AM AET5:30 (+1) IST7:30 PM VEN4:00 (+1) UAE8:00 AM SST8:00 7:00 5:00 PM MST6:00 PM CST7:00 PM EST20:00 ET19:00 21:00 BRT20:00 7:00 PM CT | Querétaro | Estadio La Corregidora | W 1-0 |
| Sat. 16 | 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET0:00 (+1) GMT1:00 0:00 12:00 AM 2:00 KSA11:00 AM AET5:30 (+1) IST7:30 PM VEN4:00 (+1) UAE8:00 AM SST8:00 7:00 5:00 PM MST6:00 PM CST7:00 PM EST20:00 ET19:00 21:00 BRT20:00 7:00 PM CT | Toluca | Estadio Universitario de Nuevo Leon | W 3-0 |
| Tue. 19 | 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET0:00 (+1) GMT1:00 0:00 12:00 AM 2:00 KSA11:00 AM AET5:30 (+1) IST7:30 PM VEN4:00 (+1) UAE8:00 AM SST8:00 7:00 5:00 PM MST6:00 PM CST7:00 PM EST20:00 ET19:00 21:00 BRT20:00 7:00 PM CT | Necaxa | Estadio Victoria de Aguascalientes | L 0-2 |
| Sat. 23 | 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET0:00 (+1) GMT1:00 0:00 12:00 AM 2:00 KSA11:00 AM AET5:30 (+1) IST7:30 PM VEN4:00 (+1) UAE8:00 AM SST8:00 7:00 5:00 PM MST6:00 PM CST7:00 PM EST20:00 ET19:00 21:00 BRT20:00 7:00 PM CT | América | Estadio Universitario de Nuevo Leon | L 0-2 |
| Sat. 30 | 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET0:00 (+1) GMT1:00 0:00 12:00 AM 2:00 KSA11:00 AM AET5:30 (+1) IST7:30 PM VEN4:00 (+1) UAE8:00 AM SST8:00 7:00 5:00 PM MST6:00 PM CST7:00 PM EST20:00 ET19:00 21:00 BRT20:00 7:00 PM CT | Atlas | Estadio Jalisco | D 1-1 |
| May 2022 |
| Date | Time | Opponent | Venue | Result |
| Thu. 12 | 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET0:00 (+1) GMT1:00 0:00 12:00 AM 2:00 KSA11:00 AM AET5:30 (+1) IST7:30 PM VEN4:00 (+1) UAE8:00 AM SST8:00 7:00 5:00 PM MST6:00 PM CST7:00 PM EST20:00 ET19:00 21:00 BRT20:00 7:00 PM CT | Cruz Azul | Estadio Azteca | W 1-0 |
| Sun. 15 | 6:05 PM PT7:05 PM MT8:05 PM CT9:05 PM ET1:05 (+1) GMT2:05 1:05 1:05 AM 3:05 KSA12:05 AM AET6:35 (+1) IST8:35 PM VEN5:05 (+1) UAE9:05 AM SST9:05 8:05 6:05 PM MST7:05 PM CST8:05 PM EST21:05 ET20:05 22:05 BRT21:05 8:05 PM CT | Cruz Azul | Estadio Universitario de Nuevo Leon | L 0-1 |
| Wed. 18 | 7:00 PM PT8:00 PM MT9:00 PM CT10:00 PM ET2:00 (+1) GMT3:00 2:00 2:00 AM 4:00 KSA13:00 AM AET7:30 (+1) IST9:30 PM VEN6:00 (+1) UAE10:00 AM SST10:00 9:00 7:00 PM MST8:00 PM CST9:00 PM EST22:00 ET21:00 23:00 BRT22:00 9:00 PM CT | Atlas | Estadio Jalisco | L 0-3 |
| Sat. 21 | 6:00 PM PT7:00 PM MT8:00 PM CT9:00 PM ET1:00 (+1) GMT2:00 1:00 1:00 AM 3:00 KSA12:00 AM AET6:30 (+1) IST8:30 PM VEN5:00 (+1) UAE9:00 AM SST9:00 8:00 6:00 PM MST7:00 PM CST8:00 PM EST21:00 ET20:00 22:00 BRT21:00 8:00 PM CT | Atlas | Estadio Universitario de Nuevo Leon | W 4-2 |
@STATS_Football
