| January 2022 |
| Date | Time | Opponent | Venue | Result |
| Fri. 7 | 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET1:00 (+1) GMT2:00 1:00 1:00 AM 3:00 KSA12:00 AM AET6:30 (+1) IST8:30 PM VEN5:00 (+1) UAE9:00 AM SST9:00 8:00 6:00 PM MST7:00 PM CST8:00 PM EST20:00 ET20:00 21:00 BRT21:00 6:00 PM CT | Necaxa | Estadio Olimpico Benito Juarez | W 2-1 |
| Sat. 15 | 7:00 PM PT8:00 PM MT9:00 PM CT10:00 PM ET3:00 (+1) GMT4:00 3:00 3:00 AM 5:00 KSA14:00 AM AET8:30 (+1) IST10:30 PM VEN7:00 (+1) UAE11:00 AM SST11:00 10:00 8:00 PM MST9:00 PM CST10:00 PM EST22:00 ET22:00 23:00 BRT23:00 8:00 PM CT | Cruz Azul | Estadio Azteca | L 0-1 |
| Thu. 20 | 7:00 PM PT8:00 PM MT9:00 PM CT10:00 PM ET3:00 (+1) GMT4:00 3:00 3:00 AM 5:00 KSA14:00 AM AET8:30 (+1) IST10:30 PM VEN7:00 (+1) UAE11:00 AM SST11:00 10:00 8:00 PM MST9:00 PM CST10:00 PM EST22:00 ET22:00 23:00 BRT23:00 8:00 PM CT | Atlético de San Luis | Estadio Alfonso Lastras Ramirez | |
| February 2022 |
| Date | Time | Opponent | Venue | Result |
| Sat. 5 | 7:00 PM PT8:00 PM MT9:00 PM CT10:00 PM ET3:00 (+1) GMT4:00 3:00 3:00 AM 5:00 KSA14:00 AM AET8:30 (+1) IST10:30 PM VEN7:00 (+1) UAE11:00 AM SST11:00 10:00 8:00 PM MST9:00 PM CST10:00 PM EST22:00 ET22:00 23:00 BRT23:00 8:00 PM CT | Guadalajara | Estadio Olimpico Benito Juarez | |
| Fri. 18 | 7:00 PM PT8:00 PM MT9:00 PM CT10:00 PM ET3:00 (+1) GMT4:00 3:00 3:00 AM 5:00 KSA14:00 AM AET8:30 (+1) IST10:30 PM VEN7:00 (+1) UAE11:00 AM SST11:00 10:00 8:00 PM MST9:00 PM CST10:00 PM EST22:00 ET22:00 23:00 BRT23:00 8:00 PM CT | Santos | Estadio Olimpico Benito Juarez | |
| Fri. 25 | 7:00 PM PT8:00 PM MT9:00 PM CT10:00 PM ET3:00 (+1) GMT4:00 3:00 3:00 AM 5:00 KSA14:00 AM AET8:30 (+1) IST10:30 PM VEN7:00 (+1) UAE11:00 AM SST11:00 10:00 8:00 PM MST9:00 PM CST10:00 PM EST22:00 ET22:00 0:00 BRT23:00 8:00 PM CT | Tigres | Estadio Olimpico Benito Juarez | |
| March 2022 |
| Date | Time | Opponent | Venue | Result |
| Tue. 1 | 5:00 PM PT6:00 PM MT7:00 PM CT8:00 PM ET1:00 (+1) GMT2:00 1:00 1:00 AM 3:00 KSA12:00 AM AET6:30 (+1) IST8:30 PM VEN5:00 (+1) UAE9:00 AM SST9:00 8:00 6:00 PM MST7:00 PM CST8:00 PM EST20:00 ET20:00 22:00 BRT21:00 6:00 PM CT | Puebla | Estadio Cuauhtemoc | |
| Fri. 4 | 7:00 PM PT8:00 PM MT9:00 PM CT10:00 PM ET3:00 (+1) GMT4:00 3:00 3:00 AM 5:00 KSA14:00 AM AET8:30 (+1) IST10:30 PM VEN7:00 (+1) UAE11:00 AM SST11:00 10:00 8:00 PM MST9:00 PM CST10:00 PM EST22:00 ET22:00 0:00 BRT23:00 8:00 PM CT | León | Estadio Olimpico Benito Juarez | |
| Tue. 8 | 7:00 PM PT8:00 PM MT9:00 PM CT10:00 PM ET3:00 (+1) GMT4:00 3:00 3:00 AM 5:00 KSA14:00 AM AET8:30 (+1) IST10:30 PM VEN7:00 (+1) UAE11:00 AM SST11:00 10:00 8:00 PM MST9:00 PM CST10:00 PM EST22:00 ET22:00 0:00 BRT23:00 8:00 PM CT | Monterrey | Estadio BBVA | |
| Fri. 11 | 7:00 PM PT8:00 PM MT9:00 PM CT10:00 PM ET3:00 (+1) GMT4:00 3:00 3:00 AM 5:00 KSA14:00 AM AET8:30 (+1) IST10:30 PM VEN7:00 (+1) UAE11:00 AM SST11:00 10:00 8:00 PM MST9:00 PM CST10:00 PM EST22:00 ET22:00 0:00 BRT23:00 8:00 PM CT | Atlas | Estadio Olimpico Benito Juarez | |
| Fri. 18 | 8:00 PM PT9:00 PM MT10:00 PM CT11:00 PM ET3:00 (+1) GMT4:00 3:00 3:00 AM 5:00 KSA14:00 AM AET8:30 (+1) IST10:30 PM VEN7:00 (+1) UAE11:00 AM SST11:00 10:00 8:00 PM MST9:00 PM CST10:00 PM EST23:00 ET22:00 0:00 BRT23:00 9:00 PM CT | Tijuana | Estadio Caliente | |
| April 2022 |
| Date | Time | Opponent | Venue | Result |
| Sat. 2 | 8:00 PM PT9:00 PM MT10:00 PM CT11:00 PM ET3:00 (+1) GMT4:00 3:00 3:00 AM 5:00 KSA14:00 AM AET8:30 (+1) IST10:30 PM VEN7:00 (+1) UAE11:00 AM SST11:00 10:00 8:00 PM MST9:00 PM CST10:00 PM EST23:00 ET22:00 0:00 BRT23:00 9:00 PM CT | Pumas | Estadio Olimpico Benito Juarez | |
| Sat. 9 | 7:00 PM PT8:00 PM MT9:00 PM CT10:00 PM ET2:00 (+1) GMT3:00 2:00 2:00 AM 4:00 KSA13:00 AM AET7:30 (+1) IST9:30 PM VEN6:00 (+1) UAE10:00 AM SST10:00 9:00 7:00 PM MST8:00 PM CST9:00 PM EST22:00 ET21:00 23:00 BRT22:00 9:00 PM CT | América | Estadio Azteca | |
| Fri. 15 | 7:00 PM PT8:00 PM MT9:00 PM CT10:00 PM ET2:00 (+1) GMT3:00 2:00 2:00 AM 4:00 KSA13:00 AM AET7:30 (+1) IST9:30 PM VEN6:00 (+1) UAE10:00 AM SST10:00 9:00 7:00 PM MST8:00 PM CST9:00 PM EST22:00 ET21:00 23:00 BRT22:00 9:00 PM CT | Pachuca | Estadio Olimpico Benito Juarez | |
| Tue. 19 | 7:00 PM PT8:00 PM MT9:00 PM CT10:00 PM ET2:00 (+1) GMT3:00 2:00 2:00 AM 4:00 KSA13:00 AM AET7:30 (+1) IST9:30 PM VEN6:00 (+1) UAE10:00 AM SST10:00 9:00 7:00 PM MST8:00 PM CST9:00 PM EST22:00 ET21:00 23:00 BRT22:00 9:00 PM CT | Toluca | Estadio Nemesio Diez | |
| Fri. 22 | 7:00 PM PT8:00 PM MT9:00 PM CT10:00 PM ET2:00 (+1) GMT3:00 2:00 2:00 AM 4:00 KSA13:00 AM AET7:30 (+1) IST9:30 PM VEN6:00 (+1) UAE10:00 AM SST10:00 9:00 7:00 PM MST8:00 PM CST9:00 PM EST22:00 ET21:00 23:00 BRT22:00 9:00 PM CT | Mazatlan | Estadio Olimpico Benito Juarez | |
| Sat. 30 | 3:00 PM PT4:00 PM MT5:00 PM CT6:00 PM ET22:00 GMT23:00 22:00 10:00 PM 0:00 KSA9:00 AM AET3:30 (+1) IST5:30 PM VEN2:00 (+1) UAE6:00 AM SST6:00 5:00 3:00 PM MST4:00 PM CST5:00 PM EST18:00 ET17:00 19:00 BRT18:00 5:00 PM CT | Querétaro | Estadio La Corregidora | |
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