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| bett1HULKS Indoors | ||
| Surface: Hard | Date: Oct. 12 - Oct. 18 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Gilles Simon | Win | 6-4, 7-6 (7-5) |
| Quarterfinals | Hubert Hurkacz | Win | 7-6 (7-4), 5-7, 6-0 |
| Semifinals | Felix Auger-Aliassime | Loss | 3-6, 6-1, 3-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: Sep. 27 - Oct. 11 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Richard Gasquet | Win | 7-6 (7-5), 6-2, 6-1 |
| Second Round | Attila Balazs | Win | 6-3, 6-1, 6-2 |
| Third Round | Pablo Carreno Busta | Loss | 4-6, 3-6, 7-5, 4-6 |
| Hamburg European Open | ||
| Surface: Red Clay | Date: Sep. 21 - Sep. 27 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Nikoloz Basilashvili | Win | 6-4, 6-3 |
| Second Round | Dominik Koepfer | Win | 6-3, 3-6, 6-3 |
| Quarterfinals | Andrey Rublev | Loss | 2-6, 5-7 |
| US Open | ||
| Surface: Hard | Date: Aug. 31 - Sep. 13 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Tennys Sandgren | Win | 6-4, 6-4, 7-6 (7-3) |
| Second Round | Miomir Kecmanovic | Win | 6-3, 3-6, 6-3, 6-4 |
| Third Round | Vasek Pospisil | Loss | 5-7, 6-2, 6-4, 3-6, 2-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 22 - Aug. 29 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Richard Gasquet | Win | 7-5, 6-1 |
| Third Round | Karen Khachanov | Win | 4-6, 6-3, 6-2 |
| Quarterfinals | Daniil Medvedev | Win | 1-6, 6-4, 6-3 |
| Semifinals | Novak Djokovic | Loss | 6-4, 4-6, 6-7 (0-7) |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 24 - Feb. 29 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Jan-Lennard Struff | Loss | 6-7 (2-7), 5-7 |
| ABN AMRO World Tennis Tournament | ||
| Surface: Hard | Date: Feb. 10 - Feb. 16 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Marton Fucsovics | Win | 4-6, 7-6 (7-1), 6-1 |
| Second Round | Pablo Carreno Busta | Loss | 4-6, 6-2, 6-7 (4-7) |
| Australian Open | ||
| Surface: Hard | Date: Jan. 20 - Feb. 2 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Feliciano Lopez | Win | 6-2, 6-2, 7-5 |
| Second Round | Michael Mmoh | Win | 5-7, 6-2, 6-4, 6-1 |
| Third Round | Marin Cilic | Loss | 7-6 (7-3), 4-6, 0-6, 7-5, 3-6 |
