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| VTB Kremlin Cup | ||
| Surface: Hard | Date: Oct. 14 - Oct. 20 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Philipp Kohlschreiber | Loss | 3-6, 6-7 (3-7) |
| Moselle Open | ||
| Surface: Hard | Date: Sep. 16 - Sep. 22 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Jan-Lennard Struff | Win | 7-6 (7-3), 6-4 |
| Second Round | Jo-Wilfried Tsonga | Loss | 3-6, 4-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 26 - Sep. 8 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Alex De Minaur | Loss | 4-6, 2-6, 7-6 (8-6), 5-7 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 11 - Aug. 18 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Sam Querrey | Loss | 6-7 (2-7), 6-7 (1-7) |
| Coupe Rogers presentee par Banque Nationale | ||
| Surface: Hard | Date: Aug. 5 - Aug. 11 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Denis Shapovalov | Loss | 3-6, 5-7 |
| Citi Open | ||
| Surface: Hard | Date: Jul. 29 - Aug. 4 | Seed: 15 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Miomir Kecmanovic | Loss | 6-3, 4-6, 6-7 (5-7) |
| BB&T Atlanta Open | ||
| Surface: Hard | Date: Jul. 22 - Jul. 28 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alexei Popyrin | Loss | 5-7, 3-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 1 - Jul. 14 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Kevin Anderson | Loss | 3-6, 4-6, 2-6 |
| Nature Valley International | ||
| Surface: Grass | Date: Jun. 23 - Jun. 29 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Denis Kudla | Win | 5-7, 7-6 (10-8), 6-4 |
| Second Round | Daniel Evans | Loss | 3-6, 5-7 |
| Noventi Open | ||
| Surface: Grass | Date: Jun. 17 - Jun. 23 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Gael Monfils | Win | 7-6 (8-6), 6-4 |
| Second Round | Sergiy Stakhovsky | Win | 2-6, 7-6 (7-2), 6-4 |
| Quarterfinals | Borna Coric | Win | 7-5, 0-0 Retired |
| Semifinals | Roger Federer | Loss | 3-6, 3-6 |
| Libema Open | ||
| Surface: Grass | Date: Jun. 10 - Jun. 16 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Matthew Ebden | Win | 6-4, 7-5 |
| Second Round | David Goffin | Loss | 3-6, 5-7 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 26 - Jun. 9 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Daniil Medvedev | Win | 4-6, 4-6, 6-3, 6-2, 7-5 |
| Second Round | Benoit Paire | Loss | 2-6, 2-6, 7-5, 7-6 (8-6), 9-11 |
| Open Parc Auvergne-Rhone-Alpes Lyon | ||
| Surface: Clay | Date: May 19 - May 25 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Jeremy Chardy | Win | 6-2, 7-5 |
| Second Round | Steve Johnson | Loss | 6-7 (6-8), 7-5, 1-6 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 4 - May 12 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Stan Wawrinka | Loss | 2-6, 3-6 |
| Gazprom Hungarian Open | ||
| Surface: Red Clay | Date: Apr. 22 - Apr. 28 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Egor Gerasimov | Win | 6-3, 6-2 |
| Second Round | Matthias Bachinger | Win | 7-5, 6-2 |
| Quarterfinals | Attila Balazs | Win | 6-3, 6-4 |
| Semifinals | Filip Krajinovic | Loss | 2-6, 2-6 |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 14 - Apr. 21 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Fernando Verdasco | Win | 6-4, 6-4 |
| Second Round | Kei Nishikori | Win | 7-5, 6-4 |
| Third Round | Borna Coric | Loss | 4-6, 2-6 |
| Grand Prix Hassan II | ||
| Surface: Red Clay | Date: Apr. 8 - Apr. 14 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Thomas Fabbiano | Win | 6-7 (3-7), 6-4, 6-1 |
| Second Round | Benoit Paire | Loss | 4-6, 2-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 19 - Mar. 31 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Filip Krajinovic | Loss | 4-6, 4-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 6 - Mar. 17 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Philipp Kohlschreiber | Loss | 4-6, 0-6 |
| ABN AMRO World Tennis Tournament | ||
| Surface: Hard | Date: Feb. 11 - Feb. 17 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Kei Nishikori | Loss | 6-3, 1-6, 4-6 |
| Open Sud de France | ||
| Surface: Hard | Date: Feb. 4 - Feb. 10 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Denis Kudla | Win | 6-2, 6-1 |
| Second Round | Ilya Ivashka | Win | 4-6, 6-4, 6-2 |
| Quarterfinals | Denis Shapovalov | Win | 7-5, 7-6 (7-4) |
| Semifinals | Tomas Berdych | Win | 6-2, 7-5 |
| Final | Jo-Wilfried Tsonga | Loss | 4-6, 2-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 14 - Jan. 27 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Sam Querrey | Win | 5-7, 7-6 (8-6), 6-3, 6-1 |
| Second Round | Hyeon Chung | Win | 6-2, 1-6, 6-2, 6-4 |
| Third Round | Milos Raonic | Loss | 4-6, 4-6, 6-7 (6-8) |
| Qatar ExxonMobil Open | ||
| Surface: Hard | Date: Dec. 31 - Jan. 5 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Dominic Thiem | Win | 6-3, 7-5 |
| Second Round | Maximilian Marterer | Win | 6-3, 6-7 (6-7), 7-6 (7-6) |
| Quarterfinals | Tomas Berdych | Loss | 2-6, 4-6 |
