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| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 11 - Aug. 18 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Casper Ruud | Win | 7-5, 7-6 (7-4) |
| Second Round | David Goffin | Loss | 1-6, 5-7 |
| Coupe Rogers presentee par Banque Nationale | ||
| Surface: Hard | Date: Aug. 5 - Aug. 11 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | David Goffin | Win | 6-4, 7-6 (7-4) |
| Second Round | Radu Albot | Win | 6-3, 2-6, 7-6 (7-2) |
| Third Round | Rafael Nadal | Loss | 3-6, 4-6 |
| Abierto Mexicano de Tenis Mifel presentado por Cinemex | ||
| Surface: Hard | Date: Jul. 29 - Aug. 3 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Grigor Dimitrov | Win | 6-4, 6-2 |
| Quarterfinals | Soon Woo Kwon | Win | 4-6, 6-1, 6-2 |
| Semifinals | Diego Schwartzman | Loss | 3-6, 6-3, 1-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 1 - Jul. 14 | Seed: 26 |
| Round | Opponent | W / L | Result |
| First Round | Marius Copil | Win | 7-6 (13-11), 5-7, 6-3, 6-4 |
| Second Round | Andreas Seppi | Win | 6-4, 4-6, 4-6, 7-5, 6-1 |
| Third Round | Kevin Anderson | Win | 6-4, 6-3, 7-6 (7-4) |
| Fourth Round | Milos Raonic | Win | 3-6, 4-6, 6-3, 7-6(7-3), 8-6 |
| Quarterfinals | Roberto Bautista Agut | Loss | 5-7, 4-6, 6-3, 3-6 |
| Nature Valley International | ||
| Surface: Grass | Date: Jun. 23 - Jun. 29 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Taylor Fritz | Loss | 4-6, 6-3, 4-6 |
| Noventi Open | ||
| Surface: Grass | Date: Jun. 17 - Jun. 23 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | David Goffin | Loss | 1-6, 1-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 26 - Jun. 9 | Seed: 19 |
| Round | Opponent | W / L | Result |
| First Round | Guido Andreozzi | Win | 7-6 (7-2), 6-4, 1-6, 6-1 |
| Second Round | Corentin Moutet | Loss | 3-6, 1-6, 6-2, 5-7 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 12 - May 19 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Taylor Fritz | Loss | 3-6, 4-6 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 4 - May 12 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Daniil Medvedev | Win | 6-2, 1-6, 6-3 |
| Second Round | Stan Wawrinka | Loss | 3-6, 4-6 |
| BMW Open by FWU | ||
| Surface: Red Clay | Date: Apr. 29 - May 5 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Mischa Zverev | Win | 6-2, 6-1 |
| Second Round | Taro Daniel | Win | 6-1, 6-7 (7-9), 6-3 |
| Quarterfinals | Roberto Bautista Agut | Loss | 6-4, 4-6, 0-6 |
| Barcelona Open Banc Sabadell | ||
| Surface: Clay | Date: Apr. 22 - Apr. 28 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Joao Sousa | Win | 3-6, 7-6 (7-1), 6-2 |
| Second Round | Karen Khachanov | Win | 6-2, 7-6 (7-4) |
| Third Round | Benoit Paire | Win | 7-5, 6-3 |
| Quarterfinals | Dominic Thiem | Loss | 5-7, 2-6 |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 14 - Apr. 21 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Laslo Djere | Win | 6-7 (2-7), 6-2, 6-4 |
| Second Round | Marin Cilic | Win | 6-3, 5-7, 6-1 |
| Third Round | Marco Cecchinato | Win | 6-4, 4-6, 6-4 |
| Quarterfinals | Rafael Nadal | Loss | 6-7 (1-7), 3-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 19 - Mar. 31 | Seed: 26 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Leonardo Mayer | Loss | 2-6, 4-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 6 - Mar. 17 | Seed: 32 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alex Bolt | Win | 7-6 (7-5), 2-6, 6-3 |
| Third Round | John Isner | Loss | 3-6, 4-6 |
| Brasil Open | ||
| Surface: Clay | Date: Feb. 25 - Mar. 3 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Roberto Carballes Baena | Win | 6-2, 6-4 |
| Quarterfinals | Marco Trungelliti | Win | 6-0, 6-3 |
| Semifinals | Laslo Djere | Win | 7-6 (12-10), 7-6 (7-1) |
| Final | Christian Garin | Win | 7-5, 6-3 |
| Rio Open presented by Claro HDTV | ||
| Surface: Clay | Date: Feb. 18 - Feb. 24 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Joao Sousa | Loss | 4-6, 6-3, 4-6 |
| Argentina Open | ||
| Surface: Clay | Date: Feb. 11 - Feb. 17 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Francisco Cerundolo | Win | 3-6, 6-4, 6-1 |
| Second Round | Leonardo Mayer | Win | 6-4, 1-6, 7-6 (7-5) |
| Quarterfinals | Jaume Munar | Win | 6-7 (3-7), 7-6 (11-9), 6-1 |
| Semifinals | Marco Cecchinato | Loss | 4-6, 2-6 |
| Cordoba Open | ||
| Surface: Clay | Date: Feb. 4 - Feb. 10 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Paolo Lorenzi | Win | 6-1, 6-3 |
| Second Round | Albert Ramos-Vinolas | Win | 6-4, 7-6 (7-4) |
| Quarterfinals | Diego Schwartzman | Win | 7-5, 6-2 |
| Semifinals | Pablo Cuevas | Win | 6-1, 3-6, 6-3 |
| Final | Juan Ignacio Londero | Loss | 6-3, 5-7, 1-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 14 - Jan. 27 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Joao Sousa | Loss | 6-7 (2-7), 6-4, 6-7 (5-7), 6-4, 2-6 |
| Qatar ExxonMobil Open | ||
| Surface: Hard | Date: Dec. 31 - Jan. 5 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Cem Ilkel | Win | 7-6 (7-1), 6-3 |
| Second Round | Marco Cecchinato | Loss | Retired |
| ASB Classic | ||
| Surface: Hard | Date: Dec. 31 - Jan. 12 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Peter Gojowczyk | Loss | 1-6, 6-3, 2-6 |
