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| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Dominic Stricker | Win | 6-3, 6-2, 6-4 |
| Second Round | Nicolas Jarry | Loss | 6-3, 1-6, 4-6, 5-7 |
| Open Parc Auvergne-Rhone-Alpes Lyon | ||
| Surface: Clay | Date: May 21 - May 27 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Gregoire Barrere | Win | 7-6 (8-6), 4-6, 6-3 |
| Quarterfinals | Brandon Nakashima | Loss | 3-6, 6-7 (4-7) |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 10 - May 21 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Cristian Garin | Loss | 6-4, 3-6, 4-6 |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 26 - May 7 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Roman Safiullin | Loss | 3-6, 6-7 (3-7) |
| Fayez Sarofim & Co. U.S. Men's Clay Court Championship | ||
| Surface: Clay | Date: Apr. 3 - Apr. 9 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yannick Hanfmann | Loss | 6-7 (6-8), 2-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 2 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marc-Andrea Huesler | Win | 5-7, 6-3, 6-4 |
| Third Round | Alejandro Davidovich Fokina | Win | 6-3, 7-5 |
| Fourth Round | Carlos Alcaraz | Loss | 4-6, 4-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 17 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jan-Lennard Struff | Win | 6-3, 6-3 |
| Third Round | Hubert Hurkacz | Win | 4-6, 6-2, 6-4 |
| Fourth Round | Felix Auger-Aliassime | Loss | 6-3, 3-6, 6-7 (6-8) |
| Abierto Mexicano Telcel presentado por HSBC | ||
| Surface: Hard | Date: Feb. 26 - Mar. 4 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Emilio Gomez | Win | 6-1, 7-6 (7-4) |
| Second Round | Michael Mmoh | Win | 6-4, 2-2 Retired |
| Quarterfinals | Mackenzie McDonald | Win | 6-2, 6-2 |
| Semifinals | Taylor Fritz | Win | 6-3, 6-7 (2-7), 7-6 (7-2) |
| Final | Alex De Minaur | Loss | 6-3, 4-6, 1-6 |
| Delray Beach Open | ||
| Surface: Hard | Date: Feb. 13 - Feb. 19 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Denis Kudla | Win | 6-3, 6-4 |
| Quarterfinals | Radu Albot | Loss | 2-6, 2-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Jan-Lennard Struff | Win | |
| Second Round | Alejandro Davidovich Fokina | Win | |
| Third Round | Jenson Brooksby | Win | |
| Fourth Round | Roberto Bautista Agut | Win | |
| Quarterfinals | Ben Shelton | Win | |
| Semifinals | Novak Djokovic | Loss |
| Adelaide International 2 | ||
| Surface: Hard | Date: Jan. 9 - Jan. 14 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Christopher O'Connell | Win | |
| Second Round | Jack Draper | Loss |
