| ||||||||||||||
| BNP Paribas Open | ||
| Surface: Hard | Date: Oct. 6 - Oct. 17 | Seed: 27 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Magda Linette | Win | 7-5, 3-0 Retired |
| Third Round | Petra Kvitova | Win | 7-5, 6-4 |
| Fourth Round | Aliaksandra Sasnovich | Win | 6-3, 6-4 |
| Quarterfinals | Jessica Pegula | Win | 6-4, 6-2 |
| Semifinals | Jelena Ostapenko | Win | 3-6, 6-3, 7-5 |
| Final | Paula Badosa | Loss | 6-7 (5-7), 6-2, 6-7 (2-7) |
| Chicago Fall Tennis Classic | ||
| Surface: Hard | Date: Sep. 27 - Oct. 3 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Shuai Zhang | Win | 6-2, 6-1 |
| Second Round | Hailey Baptiste | Win | 6-2, 4-6, 6-3 |
| Third Round | Garbine Muguruza | Loss | Retired |
| US Open | ||
| Surface: Hard | Date: Aug. 30 - Sep. 12 | Seed: 18 |
| Round | Opponent | W / L | Result |
| First Round | Tereza Martincova | Win | 6-4, 6-0 |
| Second Round | Jasmine Paolini | Win | 6-3, 7-6 (7-1) |
| Third Round | Garbine Muguruza | Loss | 4-6, 6-3, 2-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 15 - Aug. 22 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Liudmila Samsonova | Win | 6-2, 6-3 |
| Second Round | Alison Riske | Win | 6-2, 7-5 |
| Third Round | Ashleigh Barty | Loss | 0-6, 2-6 |
| National Bank Open presented by Rogers | ||
| Surface: Hard | Date: Aug. 9 - Aug. 15 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Sorana Cirstea | Win | 6-2, 6-2 |
| Third Round | Maria Sakkari | Win | 6-4, 3-6, 7-6 (7-2) |
| Quarterfinals | Aryna Sabalenka | Loss | 2-6, 4-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 28 - Jul. 11 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Kateryna Kozlova | Win | 6-1, 6-3 |
| Second Round | Sorana Cirstea | Loss | 6-7 (5-7), 6-3, 4-6 |
| Bad Homburg Open | ||
| Surface: Grass | Date: Jun. 20 - Jun. 26 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Yuliya Hatouka | Win | 7-5, 6-0 |
| Second Round | Alize Cornet | Win | 6-4, 3-6, 7-6 (9-7) |
| Quarterfinals | Sara Sorribes Tormo | Loss | Retired |
| bett1open | ||
| Surface: Grass | Date: Jun. 14 - Jun. 20 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Andrea Petkovic | Win | 6-4, 7-6 (7-2) |
| Second Round | Angelique Kerber | Win | 6-3, 7-5 |
| Quarterfinals | Jessica Pegula | Win | 6-2, 5-7, 6-4 |
| Semifinals | Liudmila Samsonova | Loss | 4-6, 2-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 30 - Jun. 13 | Seed: 15 |
| Round | Opponent | W / L | Result |
| First Round | Svetlana Kuznetsova | Win | 6-4, 2-6, 6-3 |
| Second Round | Clara Tauson | Win | 7-5, 6-4 |
| Third Round | Madison Keys | Win | 6-2, 6-2 |
| Fourth Round | Anastasia Pavlyuchenkova | Loss | 7-5, 3-6, 2-6 |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 29 - May 9 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Ekaterina Alexandrova | Win | 7-5, 3-6, 6-1 |
| Second Round | Jessica Pegula | Loss | Retired |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 23 - Apr. 4 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Laura Siegemund | Win | Retired |
| Third Round | Angelique Kerber | Win | 7-5, 6-2 |
| Fourth Round | Ashleigh Barty | Loss | 1-6, 6-1, 2-6 |
| Qatar Total Open 2021 | ||
| Surface: Hard | Date: Mar. 1 - Mar. 6 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Svetlana Kuznetsova | Win | 6-2, 6-3 |
| Second Round | Laura Siegemund | Win | 6-4, 6-2 |
| Quarterfinals | Elina Svitolina | Win | 6-2, 6-4 |
| Semifinals | Garbine Muguruza | Loss | Retired |
| Australian Open | ||
| Surface: Hard | Date: Feb. 8 - Feb. 21 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Jessica Pegula | Loss | 5-7, 4-6 |
| Grampians Trophy | ||
| Surface: Hard | Date: Feb. 3 - Feb. 7 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yulia Putintseva | Win | 6-4, 1-6, 11-9 |
| Quarterfinals | Anett Kontaveit | Loss | Retired |
