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| VTB Kremlin Cup | ||
| Surface: Hard | Date: Oct. 18 - Oct. 24 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Tereza Martincova | Win | 6-4, 4-6, 6-3 |
| Quarterfinals | Anett Kontaveit |
| BNP Paribas Open | ||
| Surface: Hard | Date: Oct. 6 - Oct. 17 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ajla Tomljanovic | Loss | 3-6, 6-1, 3-6 |
| Chicago Fall Tennis Classic | ||
| Surface: Hard | Date: Sep. 27 - Oct. 3 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ann Li | Win | 6-4, 6-4 |
| Third Round | Victoria Azarenka | Win | Retired |
| Quarterfinals | Mai Hontama | Win | 6-3, 6-2 |
| Semifinals | Marketa Vondrousova | Win | Retired |
| Final | Ons Jabeur | Win | 3-6, 6-3, 6-0 |
| US Open | ||
| Surface: Hard | Date: Aug. 30 - Sep. 12 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Donna Vekic | Win | 7-6 (7-4), 7-6 (7-5) |
| Second Round | Andrea Petkovic | Win | 6-4, 6-2 |
| Third Round | Victoria Azarenka | Win | 6-4, 3-6, 6-2 |
| Fourth Round | Barbora Krejcikova | Loss | 3-6, 6-7 (4-7) |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 15 - Aug. 22 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Caroline Garcia | Win | 6-4, 6-3 |
| Third Round | Barbora Krejcikova | Loss | 1-6, 7-6 (7-5), 2-6 |
| National Bank Open presented by Rogers | ||
| Surface: Hard | Date: Aug. 9 - Aug. 15 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Katerina Siniakova | Loss | 2-6, 6-0, 3-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 28 - Jul. 11 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Fiona Ferro | Win | 6-0, 6-1 |
| Second Round | Lesley Pattinama Kerkhove | Win | 6-1, 6-4 |
| Third Round | Ons Jabeur | Loss | 7-5, 3-6, 2-6 |
| bett1open | ||
| Surface: Grass | Date: Jun. 14 - Jun. 20 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Sorana Cirstea | Win | 6-3, 6-2 |
| Second Round | Elena Rybakina | Win | 6-4, 6-3 |
| Quarterfinals | Alize Cornet | Loss | 6-4, 3-6, 6-7 (5-7) |
| Roland Garros | ||
| Surface: Red Clay | Date: May 30 - Jun. 13 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Marta Kostyuk | Loss | 1-6, 4-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 9 - May 16 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Patricia Maria Tig | Win | 6-1, 6-2 |
| Second Round | Bernarda Pera | Win | 2-6, 6-0, 7-5 |
| Third Round | Elina Svitolina | Loss | 4-6, 2-6 |
| Volvo Car Open | ||
| Surface: Green Clay | Date: Apr. 5 - Apr. 11 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Magdalena Frech | Win | 6-1, 6-3 |
| Third Round | Yulia Putintseva | Loss | 6-0, 2-2 Retired |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 23 - Apr. 4 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Xinyu Wang | Win | 6-4, 6-1 |
| Third Round | Anna Kalinskaya | Win | 4-6, 6-3, 6-4 |
| Fourth Round | Bianca Andreescu | Loss | 6-3, 3-6, 2-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Mar. 7 - Mar. 13 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Irina-Camelia Begu | Win | 6-3, 7-5 |
| Second Round | Amanda Anisimova | Win | 6-4, 6-2 |
| Third Round | Iga Swiatek | Win | 6-0, 6-4 |
| Quarterfinals | Aryna Sabalenka | Win | 3-6, 6-3, 6-2 |
| Semifinals | Elise Mertens | Win | 6-4, 7-6 (7-5) |
| Final | Barbora Krejcikova | Win | 7-6 (8-6), 6-3 |
| Qatar Total Open 2021 | ||
| Surface: Hard | Date: Mar. 1 - Mar. 6 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Veronika Kudermetova | Win | 6-2, 7-6 (7-4) |
| Second Round | Aryna Sabalenka | Win | 6-2, 6-7 (5-7), 6-3 |
| Quarterfinals | Maria Sakkari | Win | 6-3, 6-1 |
| Semifinals | Victoria Azarenka | Win | Retired |
| Final | Petra Kvitova | Loss | 2-6, 1-6 |
| Australian Open | ||
| Surface: Hard | Date: Feb. 8 - Feb. 21 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Margarita Gasparyan | Win | 6-4, 6-0 |
| Second Round | Liudmila Samsonova | Win | 6-3, 6-1 |
| Third Round | Zarina Diyas | Win | 6-1, 6-1 |
| Fourth Round | Naomi Osaka | Loss | 6-4, 4-6, 5-7 |
| Yarra Valley Classic | ||
| Surface: Hard | Date: Jan. 31 - Feb. 6 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alison Van Uytvanck | Win | 6-2, 6-0 |
| Third Round | Anastasia Pavlyuchenkova | Win | 6-1, 6-2 |
| Quarterfinals | Sofia Kenin | Win | 6-2, 6-2 |
| Semifinals | Marketa Vondrousova | Win | 6-1, 6-0 |
| Final | Ashleigh Barty | Loss | 6-7 (3-7), 4-6 |
| Abu Dhabi WTA Women's Tennis Open | ||
| Surface: Hard | Date: Jan. 6 - Jan. 13 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Kristina Mladenovic | Win | 6-2, 6-4 |
| Second Round | Aliaksandra Sasnovich | Win | 6-1, 6-4 |
| Third Round | Maria Sakkari | Loss | 5-7, 4-6 |
