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| US Open | ||
| Surface: Hard | Date: Aug. 26 - Sep. 8 | Seed: 24 |
| Round | Opponent | W / L | Result |
| First Round | Alison Riske | Loss | 6-2, 1-6, 3-6 |
| Western & Southern Womens Open | ||
| Surface: Hard | Date: Aug. 11 - Aug. 18 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Madison Keys | Loss | 7-6 (7-4), 6-7 (5-7), 4-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 1 - Jul. 14 | Seed: 26 |
| Round | Opponent | W / L | Result |
| First Round | Beatriz Haddad Maia | Loss | 4-6, 4-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 26 - Jun. 9 | Seed: 19 |
| Round | Opponent | W / L | Result |
| First Round | Taylor Townsend | Win | 5-7, 6-2, 6-2 |
| Second Round | Johanna Larsson | Win | 6-4, 6-1 |
| Third Round | Elina Svitolina | Win | 6-3, 6-3 |
| Fourth Round | Sloane Stephens | Loss | 4-6, 3-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 12 - May 19 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Saisai Zheng | Win | 6-3, 6-4 |
| Second Round | Danielle Collins | Win | 6-4, 4-6, 6-2 |
| Third Round | Victoria Azarenka | Loss | 4-6, 1-3 Retired |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 4 - May 12 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Petra Martic | Loss | 5-7, 6-7 (2-7) |
| Abierto GNP Seguros | ||
| Surface: Hard | Date: Apr. 1 - Apr. 7 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Elena-Gabriela Ruse | Win | 6-4, 7-6 (7-4) |
| Second Round | Margarita Gasparyan | Win | 6-3, 6-7 (1-7), 6-2 |
| Quarterfinals | Kristina Mladenovic | Win | 6-1, 7-6 (7-5) |
| Semifinals | Magdalena Rybarikova | Win | 6-2, 6-3 |
| Final | Victoria Azarenka | Win | 6-1, 3-1 Retired |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 19 - Mar. 31 | Seed: 20 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Monica Niculescu | Loss | 6-7 (0-7), 6-4, 2-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 6 - Mar. 17 | Seed: 20 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Lauren Davis | Win | 6-1, 6-3 |
| Third Round | Serena Williams | Win | 6-3, 1-0 Retired |
| Fourth Round | Kiki Bertens | Win | 5-7, 6-1, 6-4 |
| Quarterfinals | Bianca Andreescu | Loss | 0-6, 1-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 17 - Feb. 23 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Dayana Yastremska | Win | 4-6, 6-3, 6-3 |
| Second Round | Saisai Zheng | Win | 7-5, 6-2 |
| Third Round | Elina Svitolina | Loss | 1-6, 2-6 |
| Hua Hin Championships | ||
| Surface: Hard | Date: Jan. 28 - Feb. 3 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Sabine Lisicki | Win | 6-3, 6-4 |
| Second Round | Mona Barthel | Win | 6-3, 7-5 |
| Quarterfinals | Dayana Yastremska | Loss | 6-7 (5-7), 1-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 14 - Jan. 27 | Seed: 18 |
| Round | Opponent | W / L | Result |
| First Round | Saisai Zheng | Win | 6-2, 6-3 |
| Second Round | Johanna Konta | Win | 6-4, 6-7 (3-7), 7-5 |
| Third Round | Timea Bacsinszky | Win | 7-6 (7-5), 6-2 |
| Fourth Round | Karolina Pliskova | Loss | 3-6, 1-6 |
| Sydney International | ||
| Surface: Hard | Date: Jan. 6 - Jan. 12 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Carla Suarez Navarro | Win | 6-3, 6-4 |
| Second Round | Kiki Bertens | Loss | Retired |
