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| Toray Pan Pacific Open | ||
| Surface: Hard | Date: Sep. 17 - Sep. 23 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Belinda Bencic | Win | 6-2, 6-4 |
| Second Round | Alison Riske | Loss | 1-6, 2-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 27 - Sep. 9 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Shuai Zhang | Win | 6-3, 6-0 |
| Second Round | Karolina Muchova | Loss | 6-3, 4-6, 4-6 |
| Western & Southern Womens Open | ||
| Surface: Hard | Date: Aug. 12 - Aug. 19 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Lesia Tsurenko | Loss | 6-2, 4-6, 4-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 2 - Jul. 15 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Naomi Broady | Win | 6-2, 7-5 |
| Second Round | Alison Van Uytvanck | Loss | 7-5, 2-6, 1-6 |
| Nature Valley Classic | ||
| Surface: Grass | Date: Jun. 18 - Jun. 24 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Anastasia Pavlyuchenkova | Win | 6-1, 6-2 |
| Second Round | Barbora Strycova | Loss | 2-6, 4-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 27 - Jun. 10 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Svetlana Kuznetsova | Win | 7-6 (7-0), 6-2 |
| Second Round | Fiona Ferro | Win | 6-4, 6-3 |
| Third Round | Samantha Stosur | Win | 6-0, 6-2 |
| Fourth Round | Lesia Tsurenko | Win | 2-0 Retired |
| Quarterfinals | Maria Sharapova | Win | 6-2, 6-1 |
| Semifinals | Simona Halep | Loss | 1-6, 4-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 13 - May 20 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Daria Gavrilova | Loss | 7-5, 2-6, 6-7 (6-8) |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 5 - May 13 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Shuai Peng | Win | 6-4, 6-2 |
| Second Round | Donna Vekic | Win | 2-6, 6-4, 6-1 |
| Third Round | Daria Kasatkina | Loss | 2-6, 6-4, 3-6 |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 23 - Apr. 29 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Anastasia Pavlyuchenkova | Loss | 5-7, 0-0 Retired |
| Open Monterrey Abierto GNP Seguros | ||
| Surface: Hard | Date: Apr. 2 - Apr. 8 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Renata Zarazua | Win | 6-1, 6-1 |
| Second Round | Alison Riske | Win | 6-2, 6-3 |
| Quarterfinals | Ajla Tomljanovic | Win | 6-3, 6-0 |
| Semifinals | Ana Bogdan | Win | 6-0, 7-5 |
| Final | Timea Babos | Win | 3-6, 6-4, 6-3 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 20 - Apr. 1 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Amanda Anisimova | Win | Retired |
| Third Round | Christina McHale | Win | 6-2, 6-1 |
| Fourth Round | Sloane Stephens | Loss | 3-6, 4-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 7 - Mar. 18 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Sachia Vickery | Loss | 6-2, 5-7, 1-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 19 - Feb. 24 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Catherine Bellis | Win | 6-3, 7-5 |
| Quarterfinals | Caroline Garcia | Win | 7-5, 6-2 |
| Semifinals | Daria Kasatkina | Loss | 6-3, 6-7 (11-13), 1-6 |
| Qatar Total Open | ||
| Surface: Hard | Date: Feb. 12 - Feb. 18 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ying-Ying Duan | Win | 6-3, 6-4 |
| Third Round | Sorana Cirstea | Win | 6-0, 6-4 |
| Quarterfinals | Caroline Garcia | Win | 3-6, 6-1, 6-4 |
| Semifinals | Simona Halep | Win | Retired |
| Final | Petra Kvitova | Loss | 6-3, 3-6, 4-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 28 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Jessika Ponchet | Win | 6-4, 6-3 |
| Second Round | Su-Wei Hsieh | Loss | 6-7 (1-7), 4-6 |
| Sydney International | ||
| Surface: Hard | Date: Jan. 7 - Jan. 13 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Kiki Bertens | Win | 6-3, 7-6 (8-6) |
| Quarterfinals | Daria Gavrilova | Loss | Retired |
| Brisbane International presented by Suncorp | ||
| Surface: Hard | Date: Dec. 31 - Jan. 7 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Aleksandra Krunic | Loss | 7-5, 6-7 (3-7), 2-1 Retired |
