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| VTB Kremlin Cup | ||
| Surface: Hard | Date: Oct. 18 - Oct. 24 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Ekaterina Alexandrova | Loss | 1-6, 0-1 Retired |
| BNP Paribas Open | ||
| Surface: Hard | Date: Oct. 6 - Oct. 17 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Anastasija Sevastova | Win | 6-2, 6-7 (5-7), 6-3 |
| Third Round | Danielle Collins | Win | 6-1, 6-3 |
| Fourth Round | Anna Kalinskaya | Win | 6-2, 6-2 |
| Quarterfinals | Anett Kontaveit | Win | 7-5, 6-3 |
| Semifinals | Paula Badosa | Loss | 3-6, 3-6 |
| Chicago Fall Tennis Classic | ||
| Surface: Hard | Date: Sep. 27 - Oct. 3 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Su-Wei Hsieh | Win | 6-1, 6-0 |
| Third Round | Jessica Pegula | Win | 1-6, 6-2, 6-3 |
| Quarterfinals | Elina Svitolina | Win | 6-4, 6-2 |
| Semifinals | Elena Rybakina | Win | 6-4, 3-2 Retired |
| Final | Garbine Muguruza | Loss | 6-3, 3-6, 0-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 30 - Sep. 12 | Seed: 20 |
| Round | Opponent | W / L | Result |
| First Round | Alize Cornet | Win | 7-5, 7-5 |
| Second Round | Maria Camila Osorio Serrano | Win | 6-0, 6-1 |
| Third Round | Elise Mertens | Loss | 3-6, 5-7 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 15 - Aug. 22 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Anett Kontaveit | Win | 6-2, 4-6, 7-5 |
| Second Round | Iga Swiatek | Win | 6-3, 6-3 |
| Third Round | Petra Kvitova | Loss | 1-6, 2-6 |
| National Bank Open presented by Rogers | ||
| Surface: Hard | Date: Aug. 9 - Aug. 15 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Clara Burel | Win | 6-1, 6-3 |
| Second Round | Daria Kasatkina | Win | 2-6, 6-3, 6-4 |
| Third Round | Bianca Andreescu | Win | 6-7 (5-7), 6-4, 6-1 |
| Quarterfinals | Jessica Pegula | Loss | 6-1, 6-7 (4-7), 0-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 28 - Jul. 11 | Seed: 21 |
| Round | Opponent | W / L | Result |
| First Round | Rebecca Peterson | Win | 6-2, 6-1 |
| Second Round | Venus Williams | Win | 7-5, 6-0 |
| Third Round | Garbine Muguruza | Win | 5-7, 6-3, 6-2 |
| Fourth Round | Iga Swiatek | Win | 5-7, 6-1, 6-1 |
| Quarterfinals | Aryna Sabalenka | Loss | 4-6, 3-6 |
| Nature Valley International | ||
| Surface: Grass | Date: Jun. 21 - Jun. 26 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Marketa Vondrousova | Win | 6-3, 7-6 (7-4) |
| Second Round | Jelena Ostapenko | Loss | 7-5, 4-6, 3-6 |
| Nature Valley Classic | ||
| Surface: Grass | Date: Jun. 14 - Jun. 20 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Catherine McNally | Win | 6-4, 6-2 |
| Second Round | Leylah Fernandez | Win | 6-4, 3-6, 7-6 (7-3) |
| Quarterfinals | Anastasia Potapova | Win | 6-4, 6-0 |
| Semifinals | Heather Watson | Win | 6-3, 6-3 |
| Final | Daria Kasatkina | Win | 7-5, 6-4 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 30 - Jun. 13 | Seed: 25 |
| Round | Opponent | W / L | Result |
| First Round | Yulia Putintseva | Win | 7-5, 6-2 |
| Second Round | Astra Sharma | Win | 6-2, 6-4 |
| Third Round | Magda Linette | Win | 3-6, 6-0, 6-1 |
| Fourth Round | Cori Gauff | Loss | 3-6, 1-6 |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 29 - May 9 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Yaroslava Shvedova | Win | 6-2, 6-3 |
| Second Round | Sloane Stephens | Win | 4-6, 6-1, 6-3 |
| Third Round | Belinda Bencic | Loss | 6-7 (2-7), 3-4 Retired |
| MUSC Health Women's Open | ||
| Surface: Green Clay | Date: Apr. 12 - Apr. 18 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Stefanie Voegele | Win | 6-4, 6-1 |
| Second Round | Alycia Parks | Win | 6-4, 6-0 |
| Quarterfinals | Nao Hibino | Win | 6-0, 6-1 |
| Semifinals | Danka Kovinic | Win | 6-3, 6-0 |
| Final | Astra Sharma | Loss | 6-2, 5-7, 1-6 |
| Volvo Car Open | ||
| Surface: Green Clay | Date: Apr. 5 - Apr. 11 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Martina Trevisan | Win | 6-2, 6-2 |
| Second Round | Hailey Baptiste | Win | 6-3, 6-3 |
| Third Round | Alize Cornet | Win | 5-7, 6-3, 6-3 |
| Quarterfinals | Cori Gauff | Win | 6-3, 6-3 |
| Semifinals | Danka Kovinic | Loss | 3-6, 2-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 23 - Apr. 4 | Seed: 27 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Paula Badosa | Win | 7-6 (8-6), 5-7, 7-5 |
| Third Round | Sofia Kenin | Win | 6-4, 4-6, 6-4 |
| Fourth Round | Sara Sorribes Tormo | Loss | 4-6, 6-0, 1-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Mar. 7 - Mar. 13 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Katerina Siniakova | Win | 6-2, 6-3 |
| Second Round | Elena Rybakina | Win | 7-6 (8-6), 4-6, 6-2 |
| Third Round | Jil Teichmann | Loss | 3-6, 3-6 |
| Qatar Total Open 2021 | ||
| Surface: Hard | Date: Mar. 1 - Mar. 6 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Anna Blinkova | Win | 6-2, 6-2 |
| Second Round | Karolina Pliskova | Loss | 4-6, 6-4, 5-7 |
| Australian Open | ||
| Surface: Hard | Date: Feb. 8 - Feb. 21 | Seed: 27 |
| Round | Opponent | W / L | Result |
| First Round | Andrea Petkovic | Win | 6-3, 3-6, 6-4 |
| Second Round | Anna Karolina Schmiedlova | Win | 6-3, 6-2 |
| Third Round | Naomi Osaka | Loss | 3-6, 2-6 |
| Grampians Trophy | ||
| Surface: Hard | Date: Feb. 3 - Feb. 7 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Anna Blinkova | Win | 6-1, 6-1 |
| Second Round | Angelique Kerber | Loss | 4-6, 4-6 |
| Abu Dhabi WTA Women's Tennis Open | ||
| Surface: Hard | Date: Jan. 6 - Jan. 13 | Seed: 15 |
| Round | Opponent | W / L | Result |
| First Round | Anastasia Pavlyuchenkova | Win | 7-6 (7-3), 6-3 |
| Second Round | Kateryna Bondarenko | Win | 5-7, 6-3, 6-2 |
| Third Round | Aryna Sabalenka | Loss | 2-6, 4-6 |
