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| VTB Kremlin Cup | ||
| Surface: Hard | Date: Oct. 18 - Oct. 24 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Irina Bara | Win | 6-0, 7-5 |
| Second Round | Garbine Muguruza | Loss | 4-6, 6-4, 3-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Oct. 6 - Oct. 17 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Ashlyn Krueger | Win | 6-2, 7-6 (7-1) |
| Second Round | Elina Svitolina | Loss | 2-6, 5-7 |
| Chicago Fall Tennis Classic | ||
| Surface: Hard | Date: Sep. 27 - Oct. 3 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Maria Camila Osorio Serrano | Win | 6-3, 7-5 |
| Second Round | Tamara Zidansek | Win | 6-2, 7-5 |
| Third Round | Belinda Bencic | Loss | 2-6, 6-7 (5-7) |
| J&T Banka Ostrava Open 2021 | ||
| Surface: Hard | Date: Sep. 20 - Sep. 26 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Katerina Siniakova | Win | 5-7, 6-4, 7-6 (9-7) |
| Second Round | Anastasia Pavlyuchenkova | Win | 7-6 (7-5), 7-6 (8-6) |
| Quarterfinals | Maria Sakkari | Loss | 5-7, 3-6 |
| Zavarovalnica Sava Portoroz | ||
| Surface: Hard | Date: Sep. 13 - Sep. 19 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Kristina Kucova | Win | 6-4, 6-1 |
| Second Round | Sorana Cirstea | Loss | 5-7, 2-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 30 - Sep. 12 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Victoria Azarenka | Loss | 4-6, 0-6 |
| Chicago Women's Open | ||
| Surface: Hard | Date: Aug. 22 - Aug. 28 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Sorana Cirstea | Win | 3-6, 6-3, 6-2 |
| Second Round | Su-Wei Hsieh | Win | 3-6, 6-4, 6-2 |
| Quarterfinals | Rebecca Peterson | Loss | 7-6 (7-4), 2-6, 1-4 Retired |
| National Bank Open presented by Rogers | ||
| Surface: Hard | Date: Aug. 9 - Aug. 15 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Amanda Anisimova | Loss | 1-6, 3-4 Retired |
| Livesport Prague Open | ||
| Surface: Clay | Date: Jul. 12 - Jul. 18 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Samantha Murray Sharan | Win | 6-1, 6-4 |
| Second Round | Asia Muhammad | Win | 6-3, 6-4 |
| Quarterfinals | Viktoria Kuzmova | Win | 6-2, 6-2 |
| Semifinals | Greet Minnen | Win | 6-3, 6-4 |
| Final | Barbora Krejcikova | Loss | 2-6, 0-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 28 - Jul. 11 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Alison Riske | Win | 6-2, 4-6, 6-1 |
| Second Round | Nadia Podoroska | Win | 6-3, 7-6 (7-5) |
| Third Round | Karolina Pliskova | Loss | 3-6, 3-6 |
| Nature Valley Classic | ||
| Surface: Grass | Date: Jun. 14 - Jun. 20 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Samantha Stosur | Win | 6-3, 6-4 |
| Second Round | Jelena Ostapenko | Win | 7-6 (7-4), 4-6, 6-2 |
| Quarterfinals | Daria Kasatkina | Loss | 4-6, 6-2, 0-6 |
| Nature Valley Open | ||
| Surface: Grass | Date: Jun. 7 - Jun. 13 | Seed: 17 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Caroline Dolehide | Win | 6-2, 6-3 |
| Third Round | Georgina Garcia Perez | Win | 6-1, 3-6, 6-2 |
| Quarterfinals | Nina Stojanovic | Loss | 2-6, 4-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 30 - Jun. 13 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Ivana Jorovic | Win | 6-3, 7-6 (8-6) |
| Second Round | Jessica Pegula | Loss | 3-6, 3-6 |
| Serbia Open | ||
| Surface: Red Clay | Date: May 16 - May 29 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Reka-Luca Jani | Loss | 2-6, 6-0, 5-7 |
| MUSC Health Women's Open | ||
| Surface: Green Clay | Date: Apr. 12 - Apr. 18 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Emma Navarro | Loss | 3-6, 2-3 Retired |
| Copa Colsanitas | ||
| Surface: Red Clay | Date: Apr. 5 - Apr. 11 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Leonie Kung | Win | 4-6, 6-4, 6-4 |
| Second Round | Maria Camila Osorio Serrano | Loss | 3-6, 3-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 23 - Apr. 4 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Yaroslava Shvedova | Win | 6-4, 6-2 |
| Second Round | Bianca Andreescu | Loss | 6-7 (5-7), 2-6 |
| St. Petersburg Ladies Trophy | ||
| Surface: Hard | Date: Mar. 15 - Mar. 21 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Stefanie Voegele | Win | 6-0, 4-6, 6-4 |
| Second Round | Ekaterina Alexandrova | Loss | 3-6, 4-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Mar. 7 - Mar. 13 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Kristyna Pliskova | Win | 7-6 (7-5), 6-7 (6-8), 6-3 |
| Second Round | Kiki Bertens | Win | 6-1, 6-4 |
| Third Round | Cori Gauff | Loss | 4-6, 2-6 |
| Open 6eme Sens | ||
| Surface: Hard | Date: Mar. 1 - Mar. 7 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Giulia Gatto-Monticone | Win | 6-2, 3-6, 6-2 |
| Second Round | Fiona Ferro | Loss | 2-6, 1-4 Retired |
