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| Guadalajara Open Akron | ||
| Surface: Hard | Date: Oct. 17 - Oct. 23 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Anna Kalinskaya | Loss | 3-6, 4-6 |
| AGEL Open 2022 | ||
| Surface: Hard | Date: Oct. 3 - Oct. 9 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Shelby Rogers | Win | 6-2, 6-2 |
| Second Round | Belinda Bencic | Win | Retired |
| Quarterfinals | Alycia Parks | Win | 7-6 (9-7), 6-3 |
| Semifinals | Elena Rybakina | Win | 3-6, 7-6 (7-4), 6-4 |
| Final | Iga Swiatek | Win | 5-7, 7-6 (7-4), 6-3 |
| Tallinn Open | ||
| Surface: Hard | Date: Sep. 26 - Oct. 2 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Ajla Tomljanovic | Win | 6-1, 7-6 (7-3) |
| Second Round | Marta Kostyuk | Win | |
| Quarterfinals | Beatriz Haddad Maia | Win | |
| Semifinals | Belinda Bencic | Win | |
| Final | Anett Kontaveit | Win |
| US Open | ||
| Surface: Hard | Date: Aug. 29 - Sep. 11 | Seed: 23 |
| Round | Opponent | W / L | Result |
| First Round | Fernanda Contreras Gomez | Win | 6-0, 6-4 |
| Second Round | Aleksandra Krunic | Loss | 6-2, 4-6, 2-6 |
| Tennis in the Land | ||
| Surface: Hard | Date: Aug. 21 - Aug. 27 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Francesca Di Lorenzo | Win | |
| Second Round | Bernarda Pera | Loss |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 14 - Aug. 21 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Veronika Kudermetova | Loss |
| National Bank Open presented by Rogers | ||
| Surface: Hard | Date: Aug. 8 - Aug. 14 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Karolina Pliskova | Loss |
| Livesport Prague Open | ||
| Surface: Clay | Date: Jul. 25 - Jul. 31 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Anna Blinkova | Win | |
| Second Round | Nao Hibino | Loss |
| Hamburg European Open | ||
| Surface: Red Clay | Date: Jul. 17 - Jul. 24 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Suzan Lamens | Win | |
| Second Round | Magdalena Frech | Win | |
| Quarterfinals | Anastasia Potapova | Loss |
| Hungarian Grand Prix | ||
| Surface: Hard | Date: Jul. 11 - Jul. 17 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Xiyu Wang | Loss |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 27 - Jul. 10 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Maryna Zanevska | Win | |
| Second Round | Viktorija Golubic | Win | |
| Third Round | Ajla Tomljanovic | Loss |
| Rothesay International Eastbourne | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marta Kostyuk | Loss |
| Roland Garros | ||
| Surface: Red Clay | Date: May 22 - Jun. 5 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Diane Parry | Loss |
| Qatar TotalEnergies Open | ||
| Surface: Hard | Date: Feb. 20 - Feb. 26 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Magda Linette | Win | |
| Third Round | Jelena Ostapenko | Loss |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 14 - Feb. 19 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Caroline Garcia | Win | |
| Second Round | Dayana Yastremska | Loss |
| Australian Open | ||
| Surface: Hard | Date: Jan. 17 - Jan. 30 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Andrea Petkovic | Win | |
| Second Round | Xiyu Wang | Win | |
| Third Round | Jelena Ostapenko | Win | |
| Fourth Round | Victoria Azarenka | Win | |
| Quarterfinals | Madison Keys | Loss |
| Sydney Tennis Classic | ||
| Surface: Hard | Date: Jan. 10 - Jan. 15 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jaqueline Cristian | Win | |
| Quarterfinals | Caroline Garcia | Win | |
| Semifinals | Anett Kontaveit | Win | |
| Final | Paula Badosa | Loss |
