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| WTA Finals Guadalajara | ||
| Surface: Hard | Date: Nov. 10 - Nov. 17 | Seed: 7 |
| Round | Opponent | W / L | Result |
| Round Robin | Aryna Sabalenka | Win | 6-4, 6-0 7-6 (7-4), 6-4 5-7, 4-6 |
| Round Robin | Maria Sakkari | Win | 6-4, 6-0 7-6 (7-4), 6-4 5-7, 4-6 |
| Round Robin | Iga Swiatek | Loss | 6-4, 6-0 7-6 (7-4), 6-4 5-7, 4-6 |
| Semifinals | Garbine Muguruza | Loss | 3-6, 3-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Oct. 6 - Oct. 17 | Seed: 21 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Dayana Yastremska | Win | 6-4, 2-6, 6-2 |
| Third Round | Cori Gauff | Win | 6-2, 6-2 |
| Fourth Round | Barbora Krejcikova | Win | 6-1, 7-5 |
| Quarterfinals | Angelique Kerber | Win | 6-4, 7-5 |
| Semifinals | Ons Jabeur | Win | 6-3, 6-3 |
| Final | Victoria Azarenka | Win | 7-6 (7-5), 2-6, 7-6 (7-2) |
| J&T Banka Ostrava Open 2021 | ||
| Surface: Hard | Date: Sep. 20 - Sep. 26 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Varvara Gracheva | Win | 6-2, 6-2 |
| Second Round | Anett Kontaveit | Loss | 3-6, 4-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 30 - Sep. 12 | Seed: 24 |
| Round | Opponent | W / L | Result |
| First Round | Alison Van Uytvanck | Win | 6-4, 6-3 |
| Second Round | Varvara Gracheva | Loss | 4-6, 4-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 15 - Aug. 22 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Petra Martic | Win | 4-6, 6-4, 7-6 (11-9) |
| Second Round | Aryna Sabalenka | Win | 5-7, 6-2, 7-6 (7-4) |
| Third Round | Elena Rybakina | Win | 6-2, 7-6 (7-5) |
| Quarterfinals | Karolina Pliskova | Loss | 5-7, 0-2 Retired |
| National Bank Open presented by Rogers | ||
| Surface: Hard | Date: Aug. 9 - Aug. 15 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Viktorija Golubic | Win | 6-2, 6-3 |
| Second Round | Rebecca Marino | Loss | 6-1, 5-7, 4-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 28 - Jul. 11 | Seed: 30 |
| Round | Opponent | W / L | Result |
| First Round | Aliona Bolsova | Win | 6-2, 5-7, 6-2 |
| Second Round | Yulia Putintseva | Win | 6-4, 6-1 |
| Third Round | Magda Linette | Win | 5-7, 6-2, 6-4 |
| Fourth Round | Karolina Muchova | Loss | 6-7 (6-8), 4-6 |
| Nature Valley International | ||
| Surface: Grass | Date: Jun. 21 - Jun. 26 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Elina Svitolina | Loss | 6-4, 1-6, 6-7 (1-7) |
| Roland Garros | ||
| Surface: Red Clay | Date: May 30 - Jun. 13 | Seed: 33 |
| Round | Opponent | W / L | Result |
| First Round | Lauren Davis | Win | 6-2, 7-6 (7-3) |
| Second Round | Danka Kovinic | Win | 6-2, 6-0 |
| Third Round | Ana Bogdan | Win | 2-6, 7-6 (7-4), 6-4 |
| Fourth Round | Marketa Vondrousova | Win | 6-4, 3-6, 6-2 |
| Quarterfinals | Tamara Zidansek | Loss | 5-7, 6-4, 6-8 |
| Serbia Open | ||
| Surface: Red Clay | Date: May 16 - May 29 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Andrea Petkovic | Win | 6-2, 6-3 |
| Second Round | Mihaela Buzarnescu | Win | 6-0, 6-4 |
| Quarterfinals | Rebecca Peterson | Win | 6-2, 6-4 |
| Semifinals | Viktoriya Tomova | Win | 6-1, 6-2 |
| Final | Ana Konjuh | Win | 6-2, 2-0 Retired |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 29 - May 9 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Barbora Krejcikova | Win | 6-1, 7-5 |
| Second Round | Jil Teichmann | Win | 5-7, 6-1, 6-2 |
| Third Round | Anastasija Sevastova | Win | 6-7 (0-7), 7-6 (7-3), 6-0 |
| Quarterfinals | Belinda Bencic | Win | 6-4, 7-5 |
| Semifinals | Ashleigh Barty | Loss | 4-6, 3-6 |
| Volvo Car Open | ||
| Surface: Green Clay | Date: Apr. 5 - Apr. 11 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Varvara Gracheva | Win | 3-6, 7-5, 6-1 |
| Second Round | Belinda Bencic | Win | 6-2, 6-7 (2-7), 6-1 |
| Third Round | Catherine McNally | Win | 6-3, 6-3 |
| Quarterfinals | Ashleigh Barty | Win | 6-4, 6-3 |
| Semifinals | Veronika Kudermetova | Loss | 3-6, 3-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 23 - Apr. 4 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Jil Teichmann | Win | 5-6 Retired |
| Second Round | Ons Jabeur | Loss | 6-7 (6-8), 7-5, 5-7 |
| St. Petersburg Ladies Trophy | ||
| Surface: Hard | Date: Mar. 15 - Mar. 21 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Jelena Ostapenko | Loss | 2-6, 2-6 |
| Open 6eme Sens | ||
| Surface: Hard | Date: Mar. 1 - Mar. 7 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Harmony Tan | Win | 6-4, 0-6, 7-6 (7-5) |
| Second Round | Stefanie Voegele | Win | 6-2, 6-4 |
| Quarterfinals | Kristina Mladenovic | Win | 7-5, 6-7 (5-7), 6-2 |
| Semifinals | Clara Tauson | Loss | 5-7, 1-6 |
| Australian Open | ||
| Surface: Hard | Date: Feb. 8 - Feb. 21 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Liudmila Samsonova | Loss | 7-6 (7-4), 6-7 (4-7), 5-7 |
| Abu Dhabi WTA Women's Tennis Open | ||
| Surface: Hard | Date: Jan. 6 - Jan. 13 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Anastasija Sevastova | Win | 6-2, 5-7, 6-2 |
| Second Round | Alize Cornet | Win | 6-4, 6-4 |
| Third Round | Veronika Kudermetova | Loss | 4-6, 6-4, 1-6 |
