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| Upper Austria Ladies Linz | ||
| Surface: Hard | Date: Nov. 7 - Nov. 12 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Aliaksandra Sasnovich | Loss | 2-6, 6-3, 2-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Oct. 6 - Oct. 17 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Irina-Camelia Begu | Loss | 2-6, 6-7 (2-7) |
| J&T Banka Ostrava Open 2021 | ||
| Surface: Hard | Date: Sep. 20 - Sep. 26 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Alison Riske | Loss | 4-6, 6-1, 4-6 |
| Zavarovalnica Sava Portoroz | ||
| Surface: Hard | Date: Sep. 13 - Sep. 19 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Bernarda Pera | Loss | 4-6, 3-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 30 - Sep. 12 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Nao Hibino | Win | 6-1, 6-4 |
| Second Round | Iga Swiatek | Loss | 6-3, 6-7 (3-7), 0-6 |
| Chicago Women's Open | ||
| Surface: Hard | Date: Aug. 22 - Aug. 28 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Aldila Sutjiadi | Win | 4-6, 7-5, 6-1 |
| Second Round | Elina Svitolina | Loss | 4-6, 4-6 |
| National Bank Open presented by Rogers | ||
| Surface: Hard | Date: Aug. 9 - Aug. 15 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Ajla Tomljanovic | Win | 2-6, 6-2, 0-0 Retired |
| Second Round | Petra Kvitova | Loss | 4-6, 4-6 |
| Ladies Championship Lausanne | ||
| Surface: Clay | Date: Jul. 12 - Jul. 18 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Harmony Tan | Win | 7-5, 6-2 |
| Second Round | Alycia Parks | Win | 6-4, 1-6, 6-0 |
| Quarterfinals | Clara Burel | Loss | 5-7, 2-6 |
| Women's Hamburg European Open | ||
| Surface: Red Clay | Date: Jul. 6 - Jul. 11 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Sara Errani | Loss | 5-7, 3-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 28 - Jul. 11 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Garbine Muguruza | Loss | 0-6, 1-6 |
| Nature Valley Classic | ||
| Surface: Grass | Date: Jun. 14 - Jun. 20 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Kristina Mladenovic | Loss | 6-3, 3-6, 4-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 30 - Jun. 13 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | En-Shuo Liang | Win | 6-1, 1-6, 6-4 |
| Second Round | Jennifer Brady | Loss | 4-6, 6-2, 5-7 |
| Tennis Championship Istanbul | ||
| Surface: Red Clay | Date: Apr. 19 - Apr. 25 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Petra Martic | Win | 7-5, 6-2 |
| Second Round | Vera Zvonareva | Win | 6-3, 6-3 |
| Quarterfinals | Sorana Cirstea | Loss | 4-6, 0-0 Retired |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 23 - Apr. 4 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Saisai Zheng | Loss | 6-2, 4-6, 3-6 |
| St. Petersburg Ladies Trophy | ||
| Surface: Hard | Date: Mar. 15 - Mar. 21 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Vera Zvonareva | Loss | 7-6 (8-6), 5-7, 6-7 (2-7) |
| Open 6eme Sens | ||
| Surface: Hard | Date: Mar. 1 - Mar. 7 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Magdalena Frech | Win | 5-7, 7-5, 7-5 |
| Second Round | Tereza Martincova | Win | 6-2, 4-1 Retired |
| Quarterfinals | Clara Burel | Win | 2-6, 6-1, 6-3 |
| Semifinals | Viktorija Golubic | Loss | 6-4, 0-6, 6-7 (4-7) |
| Australian Open | ||
| Surface: Hard | Date: Feb. 8 - Feb. 21 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Katerina Siniakova | Win | 6-7 (5-7), 6-2, 6-4 |
| Second Round | Elena Rybakina | Win | 6-4, 6-4 |
| Third Round | Iga Swiatek | Loss | 4-6, 3-6 |
| Yarra Valley Classic | ||
| Surface: Hard | Date: Jan. 31 - Feb. 6 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Shelby Rogers | Loss | 2-6, 5-7 |
