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| Upper Austria Ladies Linz | ||
| Surface: Hard | Date: Nov. 7 - Nov. 12 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Greet Minnen | Win | 6-1, 6-2 |
| Quarterfinals | Alison Van Uytvanck | Win | 7-5, 6-3 |
| Semifinals | Alison Riske | Loss | 5-7, 0-0 Retired |
| BNP Paribas Open | ||
| Surface: Hard | Date: Oct. 6 - Oct. 17 | Seed: 22 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Lauren Davis | Win | 6-1, 0-0 Retired |
| Third Round | Ons Jabeur | Loss | 1-6, 3-6 |
| Chicago Fall Tennis Classic | ||
| Surface: Hard | Date: Sep. 27 - Oct. 3 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Kirsten Flipkens | Win | 6-4, 6-2 |
| Second Round | Misaki Doi | Win | 4-6, 6-3, 7-5 |
| Third Round | Elise Mertens | Win | 6-2, 6-4 |
| Quarterfinals | Marketa Vondrousova | Loss | 7-6 (7-4), 0-6, 6-7 (3-7) |
| US Open | ||
| Surface: Hard | Date: Aug. 30 - Sep. 12 | Seed: 26 |
| Round | Opponent | W / L | Result |
| First Round | Carla Suarez Navarro | Win | 6-2, 6-4 |
| Second Round | Kaja Juvan | Win | 6-4, 6-2 |
| Third Round | Aryna Sabalenka | Loss | 3-6, 3-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 15 - Aug. 22 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Shelby Rogers | Loss | 4-6, 1-2 Retired |
| National Bank Open presented by Rogers | ||
| Surface: Hard | Date: Aug. 9 - Aug. 15 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Jil Teichmann | Win | 4-6, 6-1, 6-3 |
| Second Round | Simona Halep | Win | 2-6, 6-4, 6-4 |
| Third Round | Jessica Pegula | Loss | 4-6, 6-3, 5-7 |
| Mubadala Silicon Valley Classic | ||
| Surface: Hard | Date: Aug. 2 - Aug. 8 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Shelby Rogers | Win | 6-4, 6-3 |
| Second Round | Sloane Stephens | Win | 3-6, 6-4, 6-3 |
| Quarterfinals | Elena Rybakina | Win | 7-6 (7-5), 7-6 (7-4) |
| Semifinals | Ana Konjuh | Win | 6-0, 6-2 |
| Final | Daria Kasatkina | Win | 6-3, 6-7 (10-12), 6-1 |
| 32nd Palermo Ladies Open | ||
| Surface: Red Clay | Date: Jul. 19 - Jul. 25 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Katharina Gerlach | Win | 7-5, 6-3 |
| Second Round | Maddison Inglis | Win | 6-4, 6-1 |
| Quarterfinals | Astra Sharma | Win | 6-1, 6-4 |
| Semifinals | Shuai Zhang | Win | 6-4, 6-3 |
| Final | Elena-Gabriela Ruse | Win | 6-4, 6-2 |
| Hungarian Grand Prix | ||
| Surface: Hard | Date: Jul. 12 - Jul. 18 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Martina Di Giuseppe | Win | 6-2, 6-1 |
| Second Round | Reka-Luca Jani | Win | 7-5, 6-0 |
| Quarterfinals | Paula Ormaechea | Win | 6-1, 6-4 |
| Semifinals | Anhelina Kalinina | Loss | 6-7 (5-7), 1-4 Retired |
| Women's Hamburg European Open | ||
| Surface: Red Clay | Date: Jul. 6 - Jul. 11 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Kristina Kucova | Win | 1-6, 6-2, 6-3 |
| Quarterfinals | Elena-Gabriela Ruse | Loss | 4-6, 6-1, 5-7 |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 28 - Jul. 11 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Polona Hercog | Win | 4-6, 6-3, 6-2 |
| Second Round | Viktorija Golubic | Loss | 2-6, 0-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 30 - Jun. 13 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Xiyu Wang | Win | 6-2, 4-6, 6-4 |
| Second Round | Anhelina Kalinina | Win | 6-0, 6-2 |
| Third Round | Serena Williams | Loss | 4-6, 4-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 23 - Apr. 4 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Kristina Mladenovic | Win | 6-3, 6-3 |
| Second Round | Veronika Kudermetova | Loss | 3-6, 2-6 |
| Adelaide International | ||
| Surface: Hard | Date: Feb. 22 - Feb. 27 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Saisai Zheng | Win | 7-6 (7-5), 6-1 |
| Second Round | Ashleigh Barty | Win | 6-3, 6-4 |
| Quarterfinals | Iga Swiatek | Loss | 2-6, 0-3 Retired |
| Phillip Island Trophy | ||
| Surface: Hard | Date: Feb. 13 - Feb. 19 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Varvara Lepchenko | Win | 6-7 (3-7), 6-1, 6-3 |
| Third Round | Misaki Doi | Win | 6-4, 6-2 |
| Quarterfinals | Rebecca Peterson | Win | 6-1, 6-2 |
| Semifinals | Daria Kasatkina | Loss | 2-6, 7-6 (8-6), 1-6 |
| Australian Open | ||
| Surface: Hard | Date: Feb. 8 - Feb. 21 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Ana Bogdan | Win | 6-3, 6-1 |
| Second Round | Karolina Pliskova | Loss | 5-7, 2-6 |
| Yarra Valley Classic | ||
| Surface: Hard | Date: Jan. 31 - Feb. 6 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Ysaline Bonaventure | Win | 6-3, 6-3 |
| Second Round | Nina Stojanovic | Win | 6-2, 6-1 |
| Third Round | Karolina Pliskova | Win | 7-6 (7-5), 7-6 (7-3) |
| Quarterfinals | Serena Williams | Loss | 2-6, 6-4, 6-10 |
