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| Tenerife Ladies Open | ||
| Surface: Hard | Date: Oct. 18 - Oct. 24 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Varvara Gracheva | Loss | 4-6, 7-5, 6-7 (4-7) |
| BNP Paribas Open | ||
| Surface: Hard | Date: Oct. 6 - Oct. 17 | Seed: 28 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Anna Kalinskaya | Loss | 3-6, 6-4, 2-6 |
| J&T Banka Ostrava Open 2021 | ||
| Surface: Hard | Date: Sep. 20 - Sep. 26 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Anastasia Zakharova | Win | 6-3, 6-3 |
| Second Round | Belinda Bencic | Loss | 2-6, 3-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 30 - Sep. 12 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Karolina Muchova | Win | 6-2, 7-6 (7-3) |
| Second Round | Su-Wei Hsieh | Win | 6-1, 6-3 |
| Third Round | Emma Raducanu | Loss | 0-6, 1-6 |
| Cleveland Championships | ||
| Surface: Hard | Date: Aug. 22 - Aug. 28 | Seed: 7 |
| Round | Opponent | W / L | Result |
| Second Round | Vera Zvonareva | Win | Retired |
| First Round | Alexa Glatch | Win | 6-2, 6-1 |
| Quarterfinals | Shuai Zhang | Win | 6-3, 6-1 |
| Semifinals | Anett Kontaveit | Loss | 4-6, 4-6 |
| National Bank Open presented by Rogers | ||
| Surface: Hard | Date: Aug. 9 - Aug. 15 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Carol Zhao | Win | 6-2, 6-3 |
| Second Round | Liudmila Samsonova | Win | 6-4, 6-3 |
| Third Round | Katerina Siniakova | Win | 6-7 (4-7), 6-0, 6-3 |
| Quarterfinals | Karolina Pliskova | Loss | 4-6, 0-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 28 - Jul. 11 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Ana Konjuh | Win | 6-3, 3-6, 6-3 |
| Second Round | Angelique Kerber | Loss | 5-7, 7-5, 4-6 |
| Bad Homburg Open | ||
| Surface: Grass | Date: Jun. 20 - Jun. 26 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Martina Trevisan | Win | 6-4, 3-6, 6-2 |
| Second Round | Misaki Doi | Win | 6-4, 6-4 |
| Quarterfinals | Victoria Azarenka | Win | Retired |
| Semifinals | Katerina Siniakova | Loss | 2-6, 4-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 30 - Jun. 13 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Saisai Zheng | Loss | 6-4, 4-6, 4-6 |
| Emilia-Romagna Open | ||
| Surface: Clay | Date: May 17 - May 29 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bernarda Pera | Win | 6-4, 6-2 |
| Second Round | Sara Errani | Loss | 6-4, 5-7, 2-2 Retired |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 9 - May 16 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Camila Giorgi | Win | 7-6 (7-4), 6-7 (7-9), 7-5 |
| Second Round | Aryna Sabalenka | Loss | 5-7, 1-6 |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 29 - May 9 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Simona Halep | Loss | 0-6, 5-7 |
| Copa Colsanitas | ||
| Surface: Red Clay | Date: Apr. 5 - Apr. 11 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Sara Errani | Loss | 5-7, 5-7 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 23 - Apr. 4 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Bernarda Pera | Win | 6-2, 2-6, 7-5 |
| Second Round | Jennifer Brady | Win | 3-6, 6-4, 6-1 |
| Third Round | Elena Rybakina | Win | 6-1, 3-6, 6-2 |
| Fourth Round | Ons Jabeur | Win | 6-4, 0-6, 6-1 |
| Quarterfinals | Bianca Andreescu | Loss | 4-6, 6-3, 3-6 |
| Abierto GNP Seguros | ||
| Surface: Hard | Date: Mar. 15 - Mar. 21 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Lesia Tsurenko | Win | 5-7, 6-2, 6-4 |
| Second Round | Kaja Juvan | Win | Retired |
| Quarterfinals | Anna Karolina Schmiedlova | Win | 6-3, 7-5 |
| Semifinals | Leylah Fernandez | Loss | 5-7, 5-7 |
| Abierto de Guadalajara | ||
| Surface: Hard | Date: Mar. 8 - Mar. 14 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Greet Minnen | Win | 6-7 (4-7), 6-4, 6-1 |
| Second Round | Leonie Kung | Win | 6-3, 6-3 |
| Quarterfinals | Astra Sharma | Win | 6-3, 6-3 |
| Semifinals | Marie Bouzkova | Win | 6-3, 7-6 (7-3) |
| Final | Eugenie Bouchard | Win | 6-2, 7-5 |
| Phillip Island Trophy | ||
| Surface: Hard | Date: Feb. 13 - Feb. 19 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Liudmila Samsonova | Win | 6-7 (6-8), 6-1, 7-6 (7-4) |
| Second Round | Misaki Doi | Loss | Retired |
| Australian Open | ||
| Surface: Hard | Date: Feb. 8 - Feb. 21 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Daria Gavrilova | Loss | 1-6, 5-7 |
| Gippsland Trophy | ||
| Surface: Hard | Date: Jan. 31 - Feb. 6 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Catherine McNally | Loss | 2-6, 7-6 (7-3), 3-6 |
| Abu Dhabi WTA Women's Tennis Open | ||
| Surface: Hard | Date: Jan. 6 - Jan. 13 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Nadia Podoroska | Win | 6-3, 6-3 |
| Second Round | Bernarda Pera | Win | 5-7, 6-3, 6-4 |
| Third Round | Anastasia Gasanova | Win | 7-5, 6-3 |
| Quarterfinals | Marta Kostyuk | Loss | 6-0, 1-6, 4-6 |
