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| WTA Finals Guadalajara | ||
| Surface: Hard | Date: Nov. 10 - Nov. 17 | Seed: 4 |
| Round | Opponent | W / L | Result |
| Round Robin | Iga Swiatek | Win | 6-2, 6-4 6-7 (4-7), 4-6 7-6 (7-1), 6-7 (6-8), 6-3 |
| Round Robin | Paula Badosa | Loss | 6-2, 6-4 6-7 (4-7), 4-6 7-6 (7-1), 6-7 (6-8), 6-3 |
| Round Robin | Aryna Sabalenka | Win | 6-2, 6-4 6-7 (4-7), 4-6 7-6 (7-1), 6-7 (6-8), 6-3 |
| Semifinals | Anett Kontaveit | Loss | 1-6, 6-3, 3-6 |
| VTB Kremlin Cup | ||
| Surface: Hard | Date: Oct. 18 - Oct. 24 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Anna Kalinskaya | Win | 6-2, 1-0 Retired |
| Quarterfinals | Simona Halep | Win | 6-4, 6-4 |
| Semifinals | Ekaterina Alexandrova | Loss | 1-4 Retired |
| BNP Paribas Open | ||
| Surface: Hard | Date: Oct. 6 - Oct. 17 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Viktorija Golubic | Loss | 7-5, 3-6, 2-6 |
| J&T Banka Ostrava Open 2021 | ||
| Surface: Hard | Date: Sep. 20 - Sep. 26 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jelena Ostapenko | Win | 6-4, 6-2 |
| Quarterfinals | Tereza Martincova | Win | 7-5, 6-3 |
| Semifinals | Iga Swiatek | Win | 6-4, 7-5 |
| Final | Anett Kontaveit | Loss | 2-6, 5-7 |
| US Open | ||
| Surface: Hard | Date: Aug. 30 - Sep. 12 | Seed: 17 |
| Round | Opponent | W / L | Result |
| First Round | Marta Kostyuk | Win | 6-4, 6-3 |
| Second Round | Katerina Siniakova | Win | 6-4, 6-2 |
| Third Round | Petra Kvitova | Win | 6-4, 6-3 |
| Fourth Round | Bianca Andreescu | Win | 6-7 (2-7), 7-6 (8-6), 6-3 |
| Quarterfinals | Karolina Pliskova | Win | 6-4, 6-4 |
| Semifinals | Emma Raducanu | Loss | 1-6, 4-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 15 - Aug. 22 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Angelique Kerber | Loss | 2-6, 2-6 |
| National Bank Open presented by Rogers | ||
| Surface: Hard | Date: Aug. 9 - Aug. 15 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Marie Bouzkova | Win | 6-4, 3-1 Retired |
| Second Round | Veronika Kudermetova | Win | 6-4, 5-7, 6-4 |
| Third Round | Victoria Azarenka | Loss | 4-6, 6-3, 6-7 (2-7) |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 28 - Jul. 11 | Seed: 15 |
| Round | Opponent | W / L | Result |
| First Round | Arantxa Rus | Win | 6-1, 6-1 |
| Second Round | Shelby Rogers | Loss | 5-7, 4-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 30 - Jun. 13 | Seed: 17 |
| Round | Opponent | W / L | Result |
| First Round | Katarina Zavatska | Win | 6-4, 6-1 |
| Second Round | Jasmine Paolini | Win | 6-2, 6-3 |
| Third Round | Elise Mertens | Win | 7-5, 6-7 (2-7), 6-2 |
| Fourth Round | Sofia Kenin | Win | 6-1, 6-3 |
| Quarterfinals | Iga Swiatek | Win | 6-4, 6-4 |
| Semifinals | Barbora Krejcikova | Loss | 5-7, 6-4, 7-9 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 9 - May 16 | Seed: 17 |
| Round | Opponent | W / L | Result |
| First Round | Polona Hercog | Win | 7-6 (8-6), 3-6, 6-2 |
| Second Round | Cori Gauff | Loss | 1-6, 6-1, 1-6 |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 29 - May 9 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Amanda Anisimova | Win | 0-6, 6-1, 6-4 |
| Second Round | Anett Kontaveit | Win | 6-3, 6-1 |
| Third Round | Karolina Muchova | Loss | 0-6, 7-6 (11-9), 5-7 |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 19 - Apr. 25 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Andrea Petkovic | Win | 6-2, 6-2 |
| Second Round | Petra Kvitova | Loss | 3-6, 6-3, 3-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 23 - Apr. 4 | Seed: 23 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Arantxa Rus | Win | 6-2, 6-3 |
| Third Round | Liudmila Samsonova | Win | 6-0, 6-1 |
| Fourth Round | Jessica Pegula | Win | 6-4, 2-6, 7-6 (8-6) |
| Quarterfinals | Naomi Osaka | Win | 6-0, 6-4 |
| Semifinals | Bianca Andreescu | Loss | 6-7 (7-9), 6-3, 6-7 (4-7) |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Mar. 7 - Mar. 13 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Barbora Krejcikova | Loss | 2-6, 6-7 (4-7) |
| Qatar Total Open 2021 | ||
| Surface: Hard | Date: Mar. 1 - Mar. 6 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Mayar Sherif | Win | 6-0, 6-3 |
| Second Round | Madison Keys | Win | 6-2, 6-2 |
| Quarterfinals | Garbine Muguruza | Loss | 3-6, 1-6 |
| Australian Open | ||
| Surface: Hard | Date: Feb. 8 - Feb. 21 | Seed: 20 |
| Round | Opponent | W / L | Result |
| First Round | Kristina Mladenovic | Loss | 2-6, 6-0, 3-6 |
| Grampians Trophy | ||
| Surface: Hard | Date: Feb. 3 - Feb. 7 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Leylah Fernandez | Win | 6-2, 6-2 |
| Quarterfinals | Angelique Kerber | Win | 6-4, 6-2 |
| Semifinals | Anett Kontaveit | Loss | 6-2, 3-6, 9-11 |
| Abu Dhabi WTA Women's Tennis Open | ||
| Surface: Hard | Date: Jan. 6 - Jan. 13 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Anastasia Potapova | Win | 6-4, 6-2 |
| Second Round | Cori Gauff | Win | 7-5, 6-2 |
| Third Round | Garbine Muguruza | Win | 7-5, 6-4 |
| Quarterfinals | Sofia Kenin | Win | 2-6, 6-2, 6-0 |
| Semifinals | Aryna Sabalenka | Loss | 3-6, 2-6 |
