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| Roland Garros | ||
| Surface: Red Clay | Date: May 30 - Jun. 13 | Seed: 17 |
| Round | Opponent | W / L | Result |
| First Round | Katarina Zavatska | Win | 6-4, 6-1 |
| Second Round | Jasmine Paolini | Win | 6-2, 6-3 |
| Third Round | Elise Mertens | Win | 7-5, 6-7 (2-7), 6-2 |
| Fourth Round | Sofia Kenin | Win | 6-1, 6-3 |
| Quarterfinals | Iga Swiatek | Win | 6-4, 6-4 |
| Semifinals | Barbora Krejcikova | Loss | 5-7, 6-4, 7-9 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 9 - May 16 | Seed: 17 |
| Round | Opponent | W / L | Result |
| First Round | Polona Hercog | Win | 7-6 (8-6), 3-6, 6-2 |
| Second Round | Cori Gauff | Loss | 1-6, 6-1, 1-6 |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 29 - May 9 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Amanda Anisimova | Win | 0-6, 6-1, 6-4 |
| Second Round | Anett Kontaveit | Win | 6-3, 6-1 |
| Third Round | Karolina Muchova | Loss | 0-6, 7-6 (11-9), 5-7 |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 19 - Apr. 25 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Andrea Petkovic | Win | 6-2, 6-2 |
| Second Round | Petra Kvitova | Loss | 3-6, 6-3, 3-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 23 - Apr. 4 | Seed: 23 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Arantxa Rus | Win | 6-2, 6-3 |
| Third Round | Liudmila Samsonova | Win | 6-0, 6-1 |
| Fourth Round | Jessica Pegula | Win | 6-4, 2-6, 7-6 (8-6) |
| Quarterfinals | Naomi Osaka | Win | 6-0, 6-4 |
| Semifinals | Bianca Andreescu | Loss | 6-7 (7-9), 6-3, 6-7 (4-7) |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Mar. 7 - Mar. 13 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Barbora Krejcikova | Loss | 2-6, 6-7 (4-7) |
| Qatar Total Open 2021 | ||
| Surface: Hard | Date: Mar. 1 - Mar. 6 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Mayar Sherif | Win | 6-0, 6-3 |
| Second Round | Madison Keys | Win | 6-2, 6-2 |
| Quarterfinals | Garbine Muguruza | Loss | 3-6, 1-6 |
| Australian Open | ||
| Surface: Hard | Date: Feb. 8 - Feb. 21 | Seed: 20 |
| Round | Opponent | W / L | Result |
| First Round | Kristina Mladenovic | Loss | 2-6, 6-0, 3-6 |
| Grampians Trophy | ||
| Surface: Hard | Date: Feb. 3 - Feb. 7 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Leylah Fernandez | Win | 6-2, 6-2 |
| Quarterfinals | Angelique Kerber | Win | 6-4, 6-2 |
| Semifinals | Anett Kontaveit | Loss | 6-2, 3-6, 9-11 |
| Abu Dhabi WTA Women's Tennis Open | ||
| Surface: Hard | Date: Jan. 6 - Jan. 13 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Anastasia Potapova | Win | 6-4, 6-2 |
| Second Round | Cori Gauff | Win | 7-5, 6-2 |
| Third Round | Garbine Muguruza | Win | 7-5, 6-4 |
| Quarterfinals | Sofia Kenin | Win | 2-6, 6-2, 6-0 |
| Semifinals | Aryna Sabalenka | Loss | 3-6, 2-6 |
