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| BNP Paribas WTA Finals Shenzhen | ||
| Surface: Hard | Date: Oct. 27 - Nov. 3 | Seed: None |
| Round | Opponent | W / L | Result |
| Round Robin | Elina Svitolina | Loss | 5-7, 6-7 (10-12) |
| Hengqin Life WTA Elite Trophy | ||
| Surface: Hard | Date: Oct. 22 - Oct. 27 | Seed: 2 |
| Round | Opponent | W / L | Result |
| Round Robin | Alison Riske | Win | 6-4, 6-4 4-6, 6-4, 3-6 |
| Round Robin | Karolina Muchova | Loss | 6-4, 6-4 4-6, 6-4, 3-6 |
| China Open | ||
| Surface: Hard | Date: Sep. 28 - Oct. 6 | Seed: 15 |
| Round | Opponent | W / L | Result |
| First Round | Garbine Muguruza | Win | 6-0, 2-6, 6-2 |
| Second Round | Anastasia Pavlyuchenkova | Win | 6-3, 6-2 |
| Third Round | Elina Svitolina | Loss | 3-6, 7-6 (10-8), 3-6 |
| Dongfeng Motor Wuhan Open | ||
| Surface: Hard | Date: Sep. 22 - Sep. 28 | Seed: 15 |
| Round | Opponent | W / L | Result |
| First Round | Anastasia Pavlyuchenkova | Win | 6-2, 7-6 (7-5) |
| Second Round | Elise Mertens | Win | 4-6, 6-4, 7-6 (7-5) |
| Third Round | Ashleigh Barty | Loss | 3-6, 5-7 |
| Guangzhou International Women's Open | ||
| Surface: Hard | Date: Sep. 16 - Sep. 21 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Laura Siegemund | Win | 6-4, 6-2 |
| Second Round | Katarina Zavatska | Win | 6-4, 6-2 |
| Quarterfinals | Jasmine Paolini | Win | 7-5, 6-1 |
| Semifinals | Anna Blinkova | Win | 7-6 (7-2), 4-6, 6-1 |
| Final | Samantha Stosur | Win | 6-7 (4-7), 6-4, 6-2 |
| Zhengzhou Open | ||
| Surface: Hard | Date: Sep. 9 - Sep. 15 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Chloe Paquet | Win | 6-2, 7-5 |
| Second Round | Alize Cornet | Win | 6-4, 6-2 |
| Quarterfinals | Karolina Pliskova | Loss | 4-6, 6-4, 1-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 26 - Sep. 8 | Seed: 20 |
| Round | Opponent | W / L | Result |
| First Round | Coco Vandeweghe | Win | 7-6 (7-4), 6-3 |
| Second Round | Laura Siegemund | Win | 7-6 (7-4), 6-0 |
| Third Round | Madison Keys | Loss | 3-6, 5-7 |
| Western & Southern Womens Open | ||
| Surface: Hard | Date: Aug. 11 - Aug. 18 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Julia Goerges | Win | 6-4, 7-6 (8-6) |
| Second Round | Zarina Diyas | Win | 6-4, 6-1 |
| Third Round | Elina Svitolina | Win | 6-3, 7-6 (7-3) |
| Quarterfinals | Naomi Osaka | Win | 6-4, 1-6, 2-0 Retired |
| Semifinals | Madison Keys | Loss | 5-7, 4-6 |
| Rogers Cup presented by National Bank | ||
| Surface: Hard | Date: Aug. 5 - Aug. 11 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Su-Wei Hsieh | Win | 6-4, 6-3 |
| Second Round | Ashleigh Barty | Win | 6-7 (5-7), 6-3, 6-4 |
| Third Round | Dayana Yastremska | Win | 6-2, 6-2 |
| Quarterfinals | Elina Svitolina | Win | 7-6 (7-2), 6-4 |
| Semifinals | Bianca Andreescu | Loss | 4-6, 6-7 (5-7) |
| Citi Open | ||
| Surface: Hard | Date: Jul. 29 - Aug. 4 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Jennifer Brady | Win | 6-2, 6-4 |
| Second Round | Lauren Davis | Loss | 7-5, 3-6, 4-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 1 - Jul. 14 | Seed: 27 |
| Round | Opponent | W / L | Result |
| First Round | Astra Sharma | Win | 6-4, 6-2 |
| Second Round | Dayana Yastremska | Loss | 5-7, 6-4, 3-6 |
| Nature Valley International | ||
| Surface: Grass | Date: Jun. 23 - Jun. 29 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Samantha Stosur | Loss | 2-6, 3-6 |
| Mallorca Open | ||
| Surface: Grass | Date: Jun. 17 - Jun. 23 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Kirsten Flipkens | Win | 6-2, 6-3 |
| Second Round | Ons Jabeur | Win | 6-2, 2-0 Retired |
| Quarterfinals | Elise Mertens | Win | 1-6, 6-1, 6-3 |
| Semifinals | Anastasija Sevastova | Win | 6-4, 4-6, 6-2 |
| Final | Belinda Bencic | Win | 6-7 (2-7), 7-6 (7-5), 6-4 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 26 - Jun. 9 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Giulia Gatto-Monticone | Win | 6-3, 5-7, 6-2 |
| Second Round | Bianca Andreescu | Win | Retired |
| Third Round | Serena Williams | Win | 6-2, 7-5 |
| Fourth Round | Ashleigh Barty | Loss | 3-6, 6-3, 0-6 |
| Internationaux de Strasbourg | ||
| Surface: Clay | Date: May 19 - May 25 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Chloe Paquet | Loss | 3-6, 3-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 12 - May 19 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Jasmine Paolini | Win | 6-1, 6-2 |
| Second Round | Madison Keys | Win | 6-7 (2-7), 6-3, 6-4 |
| Third Round | Karolina Pliskova | Loss | 6-4, 4-6, 3-6 |
| Mutua Madrid Open | ||
| Surface: Hard | Date: May 4 - May 12 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Petra Kvitova | Loss | 1-6, 4-6 |
| Volvo Car Open | ||
| Surface: Green Clay | Date: Apr. 1 - Apr. 7 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Sabine Lisicki | Win | 7-5, 6-4 |
| Second Round | Monica Puig | Loss | 4-6, 4-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 19 - Mar. 31 | Seed: 32 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Bianca Andreescu | Loss | 3-6, 3-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 6 - Mar. 17 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Yafan Wang | Win | 1-6, 7-5, 6-4 |
| Second Round | Elina Svitolina | Loss | 6-3, 6-7 (5-7), 4-6 |
| Abierto Mexicano TELCEL presentado por HSBC | ||
| Surface: Hard | Date: Feb. 25 - Mar. 3 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Rebecca Peterson | Win | 4-3 Retired |
| Second Round | Katie Boulter | Win | 6-4, 4-1 Retired |
| Quarterfinals | Victoria Azarenka | Win | 6-4, 4-6, 7-5 |
| Semifinals | Bianca Andreescu | Win | 6-4, 3-6, 7-5 |
| Final | Yafan Wang | Loss | 6-2, 3-6, 5-7 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 17 - Feb. 23 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Mihaela Buzarnescu | Win | 6-3, 6-0 |
| Second Round | Daria Kasatkina | Win | 6-3, 2-6, 6-4 |
| Third Round | Viktoria Kuzmova | Loss | 6-1, 5-7, 2-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 14 - Jan. 27 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Veronika Kudermetova | Win | 6-3, 3-6, 7-5 |
| Second Round | Simona Halep | Loss | 3-6, 7-6 (7-5), 4-6 |
| Hobart International | ||
| Surface: Hard | Date: Jan. 7 - Jan. 12 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Caroline Garcia | Win | 6-3, 6-2 |
| Second Round | Ons Jabeur | Win | 7-6 (7-6), 6-3 |
| Quarterfinals | Kirsten Flipkens | Win | 7-5, 7-5 |
| Semifinals | Alize Cornet | Win | 6-2, 6-4 |
| Final | Anna Karolina Schmiedlova | Win | 6-3, 6-0 |
| ASB Classic | ||
| Surface: Hard | Date: Dec. 31 - Jan. 12 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Petra Martic | Win | 7-5, 2-6, 6-2 |
| Second Round | Viktoria Kuzmova | Loss | 5-7, 7-5, 3-6 |
